Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, the Netherlands.
J Magn Reson Imaging. 2018 Aug;48(2):507-513. doi: 10.1002/jmri.26003. Epub 2018 Mar 8.
Renal steatosis (fatty kidney) is a potential biomarker for obesity-related renal disease; however, noninvasive assessment of renal fat content remains a technical challenge.
To evaluate reproducibility and explore clinical application of renal metabolic imaging for the quantification of renal triglyceride content (TG) using proton magnetic resonance spectroscopy ( H-MRS).
Reproducibility and clinical cohort study.
Twenty-three healthy volunteers (mean age 30.1 ± 13.4 years) and 15 patients with type 2 diabetes mellitus (T2DM) (mean age 59.3 ± 7.0 years).
FIELD STRENGTH/SEQUENCE: 3T, single-voxel point resolved spectroscopy (PRESS).
Intra- and interexamination reproducibility of renal TG was assessed in healthy volunteers, and compared to T2DM patients. Intraexamination differences were obtained by repeating the H-MRS measurement directly after the first H-MRS without repositioning of the subject or changing surface coil and measurement volumes. Interexamination variability was studied by repeating the scan protocol after removal and replacement of the subject in the magnet, and subsequent repositioning of body coil and measurement volumes.
Reproducibility was determined using Pearson's correlation and Bland-Altman analyses. Differences in TG% between healthy volunteers and T2DM patients were assessed using the Mann-Whitney U-test.
After logarithmic (log) transformation, both intraexamination (r = 0.91, n = 19) and interexamination (r = 0.73, n = 9) measurements of renal TG content were highly correlated with the first renal TG measurements. Intraexamination and interexamination limits of agreement of renal log TG% were respectively [-1.36%, + 0.84%] and [-0.77%, + 0.62%]. Backtransformed limits of agreement were [-0.89%,+0.57%] and [-0.55%, + 0.43%] multiplied by mean TG for intra- and interexamination measurements. Overall median renal TG content was 0.12% [0.08, 0.22; 25th percentile, 75th percentile] in healthy volunteers and 0.20% [0.13, 0.22] in T2DM patients (P = 0.08).
Renal metabolic imaging using 3T H-MRS is a reproducible technique for the assessment of renal triglyceride content.
3 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2018;48:507-513.
肾脂肪变性（脂肪肾）是肥胖相关肾脏疾病的潜在生物标志物；然而，肾脂肪含量的无创评估仍然是一项技术挑战。
使用质子磁共振波谱（ 1 H-MRS）评估肾脏代谢成像定量测定肾脏三酰甘油（TG）含量的重复性，并探讨其临床应用。
重复性和临床队列研究。
23 名健康志愿者（平均年龄 30.1±13.4 岁）和 15 名 2 型糖尿病患者（T2DM）（平均年龄 59.3±7.0 岁）。
磁场强度/序列：3T，单体素点分辨波谱（PRESS）。
在健康志愿者中评估肾脏 TG 的内检和间检重复性，并与 T2DM 患者进行比较。通过在第一次 1 H-MRS 测量后直接重复 1 H-MRS 测量，获得内检差异，而无需重新定位受试者或改变表面线圈和测量体积。间检可通过在移除和更换受试者后重复扫描方案，并随后重新定位体线圈和测量体积来研究。
使用 Pearson 相关和 Bland-Altman 分析来确定重复性。使用 Mann-Whitney U 检验评估健康志愿者和 T2DM 患者之间的 TG%差异。
经对数（log）转换后，肾脏 TG 含量的内检（r=0.91，n=19）和间检（r=0.73，n=9）测量均与第一次肾脏 TG 测量高度相关。肾脏 log TG%的内检和间检一致性界限分别为[-1.36%，+0.84%]和[-0.77%，+0.62%]。内检和间检的转换后一致性界限分别为[-0.89%，+0.57%]和[-0.55%，+0.43%]，乘以平均 TG。健康志愿者的总体中位数肾脏 TG 含量为 0.12%[0.08，0.22；25%，75%]，2 型糖尿病患者为 0.20%[0.13，0.22]（P=0.08）。
使用 3T 1 H-MRS 的肾脏代谢成像技术是一种评估肾脏三酰甘油含量的重复性技术。
3 级技术功效：第 1 阶段 J. MAGN. RESON. IMAGING 2018;48:507-513.
