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系统神经科学方法治疗偏头痛。

A Systems Neuroscience Approach to Migraine.

机构信息

Department of Neurology, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, USA.

Department of Biomedical Sciences and Padova Neuroscience Center, University of Padova, 35131 Padova, Italy; CNR Institute of Neuroscience, Via Ugo Bassi 58/B, 35131 Padova, Italy.

出版信息

Neuron. 2018 Mar 7;97(5):1004-1021. doi: 10.1016/j.neuron.2018.01.029.

DOI:10.1016/j.neuron.2018.01.029
PMID:29518355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6402597/
Abstract

Migraine is an extremely common but poorly understood nervous system disorder. We conceptualize migraine as a disorder of sensory network gain and plasticity, and we propose that this framing makes it amenable to the tools of current systems neuroscience.

摘要

偏头痛是一种极其常见但尚未被充分了解的神经系统疾病。我们将偏头痛视为感觉网络增益和可塑性的障碍,并提出这种观点使其能够应用于当前系统神经科学的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7441/6402597/f3c2da382000/nihms934914f8.jpg
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Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.通过与蓝斑的相互作用实现杏仁核早期感觉加工的门控作用。
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3
Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms.
皮质星形胶质细胞激活引发脑膜伤害感受和偏头痛样疼痛。
Pain. 2025 Jul 30. doi: 10.1097/j.pain.0000000000003737.
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Sex differences in the effects of calcitonin gene-related peptide signaling on migraine-like behavior in animal models: a narrative review.降钙素基因相关肽信号传导对动物模型中偏头痛样行为影响的性别差异:一项叙述性综述
Front Neurol. 2025 Jul 10;16:1603758. doi: 10.3389/fneur.2025.1603758. eCollection 2025.
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Effect of High-Rate Repetitive Transcranial Magnetic Stimulation on Phonophobia and Brainstem Auditory Evoked Potential in Migraine.高频重复经颅磁刺激对偏头痛患者恐音症及脑干听觉诱发电位的影响
Mol Neurobiol. 2025 Jul 14. doi: 10.1007/s12035-025-05190-z.
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Mechanistic intersections between migraine and major depressive disorder.偏头痛与重度抑郁症之间的机制交叉点。
J Headache Pain. 2025 Jul 9;26(1):157. doi: 10.1186/s10194-025-02097-x.
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A Preliminary Meta-analysis of Regulatory T-cell Reduction in Patients With Migraine.偏头痛患者调节性T细胞减少的初步Meta分析。
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外周和中枢降钙素基因相关肽机制均可诱导小鼠出现偏头痛样畏光行为。
J Neurosci. 2017 Jan 4;37(1):204-216. doi: 10.1523/JNEUROSCI.2967-16.2016.
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