Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Odontología Médico-Quirúrgica (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
J Periodontol. 2018 Sep;89(9):1069-1074. doi: 10.1002/JPER.17-0603. Epub 2018 Aug 14.
To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross-sectional study.
We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals (n = 37), systemically healthy and CP patients (n = 19), CM and periodontally healthy patients (n = 34), and CM+CP patients (n = 48). Demographic, neurological, clinical data as well as full-mouth periodontal records were obtained. ProCT and high sensitive C-reactive protein (hs-CRP) serum levels were determined from blood samples taken during migraine interictal period.
Patients from the CP+CM group (0.056±0.006 ng/mL) had significantly higher serum proCT levels in comparison with the systemically and periodontally healthy group (0.029±0.019 ng/mL), CM group (0.041±0.002 ng/mL), or CP group (0.034±0.014 ng/mL) (p < 0.001). There were no significant differences in hs-CRP between groups (p = 0.081). Multiple linear regression analysis showed that CP was associated with increased proCT levels in CM patients (R = 0.293, p < 0.001).
CP independently contributes to elevated serum proCT levels in CM patients. These findings suggest that CP could play a role in migraine chronification.
在一项横断面研究中，评估慢性牙周炎（CP）对慢性偏头痛（CM）患者血清降钙素原（proCT）水平的影响。
我们纳入了 138 名受试者，根据 CM 和牙周参数的临床特征将其分为 4 组：系统和牙周健康者（n=37）、系统健康和 CP 患者（n=19）、CM 和牙周健康者（n=34）和 CM+CP 患者（n=48）。记录人口统计学、神经学、临床数据以及全口牙周记录。在偏头痛发作间期采集血样，检测 proCT 和高敏 C 反应蛋白（hs-CRP）血清水平。
CP+CM 组患者（0.056±0.006ng/mL）的血清 proCT 水平明显高于系统和牙周健康组（0.029±0.019ng/mL）、CM 组（0.041±0.002ng/mL）或 CP 组（0.034±0.014ng/mL）（p<0.001）。各组间 hs-CRP 无显著差异（p=0.081）。多元线性回归分析显示 CP 与 CM 患者 proCT 水平升高相关（R=0.293，p<0.001）。
CP 独立导致 CM 患者血清 proCT 水平升高。这些发现提示 CP 可能在偏头痛慢性化中起作用。
