Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, Uinted Arab Emirates.
Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Int Dent J. 2023 Aug;73(4):481-488. doi: 10.1016/j.identj.2023.04.007. Epub 2023 May 22.
Migraine is a neurologic illness that produces intense throbbing pain on one side of the head and affects roughly 1 billion people worldwide. Recent research indicates a relationship between periodontitis and chronic migraines. This study aimed to review the association between chronic migraines and periodontitis through a systematic literature review. Four research databases (Google Scholar, PubMed, ProQuest, and SpringerLink) were searched according to PRISMA guidelines to retrieve the studies included in this review. A search strategy was developed to answer the study question with appropriate inclusion and exclusion criteria. Out of 34 published studies, 8 studies were included in this review. Three of the studies were cross-sectional, 3 were case-control, and 2 were clinical report and medical hypothesis papers. Seven of the 8 included studies showed that there is an association between periodontal disease and chronic migraine. The elevated blood levels of some biomarkers such as leptins, ProCalcitonin (proCT), calcitonin gene-related peptides (CGRPs), Pentraxin 3 (PTX3), and Soluble Tumor Necrosis Factor-like Weak Inducer Of Apoptosis (sTWEAK) play a significant role in this association. The limitations include a small sample size, the influence of anti-inflammatory drugs, and a self-reported headache measure that is subject to misclassification bias. This systematic review reveals a supposed correlation between periodontal disease and chronic migraine, as evidenced by various biomarkers and inflammatory mediators. This suggests that periodontal disease could potentially contribute to the development of chronic migraine. However, to further assess the potential benefits of periodontal treatment in patients with chronic migraine, additional longitudinal studies with larger sample sizes and interventional studies are needed.
偏头痛是一种神经系统疾病，会导致头部一侧剧烈的搏动性疼痛，影响全球约 10 亿人。最近的研究表明，牙周炎与慢性偏头痛之间存在关联。本研究旨在通过系统文献回顾来综述慢性偏头痛与牙周炎之间的关系。根据 PRISMA 指南，我们在四个研究数据库（Google Scholar、PubMed、ProQuest 和 SpringerLink）中进行了搜索，以检索纳入本综述的研究。制定了搜索策略来回答研究问题，并使用适当的纳入和排除标准。在已发表的 34 项研究中，有 8 项研究纳入本综述。其中 3 项为横断面研究，3 项为病例对照研究，2 项为临床报告和医学假设论文。8 项纳入研究中有 7 项表明牙周病与慢性偏头痛之间存在关联。一些生物标志物（如瘦素、降钙素原（proCT）、降钙素基因相关肽（CGRPs）、Pentraxin 3（PTX3）和可溶性肿瘤坏死因子样弱凋亡诱导剂（sTWEAK））的血液水平升高在这种关联中起着重要作用。本研究的局限性包括样本量小、抗炎药物的影响以及头痛的自我报告测量可能存在分类偏倚。本系统综述揭示了牙周病与慢性偏头痛之间存在假定的相关性，这可以通过各种生物标志物和炎症介质来证明。这表明牙周病可能有助于慢性偏头痛的发展。然而，为了进一步评估牙周治疗对慢性偏头痛患者的潜在益处，还需要进行更多具有更大样本量和干预性研究的纵向研究。
