Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Rúa Entrerríos S/N, 15782, Santiago de Compostela, Spain.
Odontología Médico-Quirúrgica (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Odontology. 2019 Jan;107(1):90-95. doi: 10.1007/s10266-018-0360-7. Epub 2018 Apr 12.
The aim of this investigation was to examine whether chronic periodontitis (CP) is a risk indicator of chronic migraine (CM). We performed a case-control study consisted of 102 cases (patients diagnosed with CM) and 91 controls (non-CM individuals) matched by age and gender. Full-mouth periodontal charts, demographic, medical, clinical, as well as neurological data were obtained. In addition, high sensitive C-reactive protein serum levels were determined from blood samples of both cases (taken during migraine interictal period) and controls. The prevalence of CP was significantly higher in patients with CM compared to those without CM (58.8 vs. 30.8%, p < 0.0001). Logistic regression analysis showed that CP was significantly associated with the presence of CM, independently of well-known chronifying factors of migraine (OR 2.4; 95% CI 1.2-4.7; p = 0.012). Based on our results, CP could be considered as a risk indicator of CM. However, more evidence is necessary to investigate if this relationship is causal or not.
本研究旨在探讨慢性牙周炎（CP）是否是慢性偏头痛（CM）的风险指标。我们进行了一项病例对照研究，纳入了 102 例病例（诊断为 CM 的患者）和 91 例对照（非 CM 个体），这些对照按照年龄和性别进行匹配。收集了全口牙周图表、人口统计学、医学、临床和神经学数据。此外，从病例（偏头痛发作间期）和对照的血液样本中测定了高敏 C 反应蛋白血清水平。与无 CM 的患者相比，CM 患者的 CP 患病率显著更高（58.8%比 30.8%，p<0.0001）。Logistic 回归分析表明，CP 与 CM 的存在显著相关，独立于偏头痛的已知慢性化因素（OR 2.4；95%CI 1.2-4.7；p=0.012）。基于我们的结果，CP 可以被认为是 CM 的风险指标。然而，需要更多的证据来研究这种关系是否具有因果关系。
