Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Cancer Control and Population Sciences Program, University of Puerto Rico comprehensive Cancer Center, San Juan, Puerto Rico.
J Periodontol. 2018 May;89(5):540-548. doi: 10.1002/JPER.17-0372.
Despite limited data, research suggests that marijuana use is associated with oral HPV infection and periodontitis, two potential oropharyngeal cancer risk factors. We assessed these associations in a Hispanic adult population in Puerto Rico.
A cross-sectional study of 735 adults assessed marijuana use, determined through an audio computer-assisted self-interview, and periodontitis and self-collection of oral HPV samples following the National Health and Nutrition Examination Survey methodology. The Centers of Disease Control and Prevention/American Academy of Periodontology definition was used for periodontitis. HPV typing was performed using polymerase chain reaction with modified L1 consensus primers (MY09/MY11).
26.5% of adults reported lifetime use of marijuana, 2.7% were frequent users (lifetime use ≥ 26 times, past year use ≥ 6 times, and past 30-day use ≥2 times), 5.7% had oral HPV infection, and 20.1% had severe periodontitis. The multivariate logistic regression analysis showed that frequent marijuana users were more likely to have severe periodontitis (OR = (2.93, 95%: 1.08-7.96)) than never/once lifetime users after adjusting for age, sex, healthcare coverage, smoking, binge drinking, number of oral sex partners, and oral HPV infection. However, frequent marijuana use was not associated with oral HPV infection.
Marijuana use was associated with periodontitis, but not with oral HPV infection. Further evaluation of the role of marijuana use in oral HPV infection and periodontitis may inform novel preventive public health strategies, as marijuana users could be at increased risk of oral cancer.
尽管数据有限，但研究表明，大麻使用与口腔 HPV 感染和牙周炎有关，这两种因素都可能增加口咽癌的风险。我们在波多黎各的西班牙裔成年人中评估了这些关联。
一项横断面研究调查了 735 名成年人的大麻使用情况，使用音频计算机辅助自我访谈进行评估，并按照国家健康和营养调查的方法进行牙周炎和口腔 HPV 样本的自我采集。采用疾病控制与预防中心/美国牙周病学会的定义来确定牙周炎。使用聚合酶链反应（PCR）和改良的 L1 通用引物（MY09/MY11）进行 HPV 分型。
26.5%的成年人报告有过终生使用大麻，2.7%为频繁使用者（终生使用≥26 次，过去一年使用≥6 次，过去 30 天使用≥2 次），5.7%有口腔 HPV 感染，20.1%有严重牙周炎。多变量逻辑回归分析显示，频繁使用大麻者发生严重牙周炎的可能性是从不/偶尔使用大麻者的 2.93 倍（95%置信区间：1.08-7.96），校正年龄、性别、医疗保险、吸烟、狂饮、口腔性伴侣数和口腔 HPV 感染等因素后。然而，频繁使用大麻与口腔 HPV 感染无关。
大麻使用与牙周炎有关，但与口腔 HPV 感染无关。进一步评估大麻使用与口腔 HPV 感染和牙周炎之间的关系可能为新的预防公共卫生策略提供信息，因为大麻使用者可能有更高的口腔癌风险。
