Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4156-4163. doi: 10.1002/anie.201712512. Epub 2018 Mar 9.
The void between drug discovery and successful translation to humans is vast. In order to develop effective solutions, convergence of a multidisciplinary team with a range of expertise is required. In this Essay, examples of successful sustained delivery systems for antimalarials and antiretrovirals, as well as to the gastrointestinal tract are discussed.
药物发现与成功转化为人类应用之间存在巨大鸿沟。为了开发有效的解决方案，需要多学科团队的融合，汇聚各种专业知识。本文讨论了成功的抗疟药和抗逆转录病毒药物以及胃肠道持续释放系统的例子。
