Maher Sam, Casettari Luca, Illum Lisbeth
School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin 2, Ireland.
Department of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
Pharmaceutics. 2019 Jul 15;11(7):339. doi: 10.3390/pharmaceutics11070339.
Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.
在药物递送领域，人们一直在寻找能够安全、持续地促进难吸收化合物跨上皮屏障转运的药物递送系统。使用化学渗透促进剂是通过口服、鼻腔、口腔、眼部和肺部途径提高粘膜通透性的最简单且经过广泛测试的方法之一。迄今为止，只有少数渗透促进剂进入了临床试验阶段，并且只有一种含有渗透促进剂的产品进入了药品市场。这篇社论是对题为（https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers）的特刊的介绍。客座编辑概述了该特刊的范围，反思了该特刊发表的19篇文章的结果和结论，并对渗透促进剂在药物递送领域的应用前景进行了展望。
