Żebrowska Aleksandra, Hall Barbara, Kochańska-Dziurowicz Aleksandra, Janikowska Grażyna
Department of Physiological and Medical Sciences, Academy of Physical Education, Katowice, Poland.
Department of Health Care, Silesian Medical College, Katowice, Poland.
Adv Clin Exp Med. 2018 Feb;27(2):207-216. doi: 10.17219/acem/66354.
An integral part of the treatment of diabetes is physical activity. Scientific reports have shown the beneficial effects of hypoxia and exercise on cardiovascular and metabolic variables in patients with diabetes.
The aim of the study was to assess the effect of normobaric hypoxia and exercise on the serum concentrations of proangiogenic factors and glycemia in patients with type 1 diabetes.
A total of 28 adults (aged 30.4 years ±9.7 years), suffering from diabetes for 12.1 years ±6.0 years and healthy individuals, participated in the following trials: normoxic (Nor) and hypoxic (Hy) rest and Nor and Hy incremental exercise test (Ex) (FIO2 = 15.2%). The Altitude Trainer Hypoxico System (HYP-123 Hypoxic Generator, LOWOXYGEN Technology GmbH, Berlin, Germany) corresponding to a height of about 2500 m above sea level was used in the study. Exercise tests were performed on a cycle ergometer Excalibur Sport (Lode B.V., Groningen, The Netherlands). Cardiorespiratory variables, glycemia, angiogenic and hematological indices were measured at rest and in response to both exercise protocols.
The present data confirmed that the patients with type 1 diabetes demonstrated a good level of aerobic capacity and fitness. NorEx and HyEx resulted in a significant decrease in serum glucose concentration (p < 0.05 vs p < 0.01). Patients with diabetes had higher baseline hypoxia induced factor-1alpha levels compared to healthy adults (p < 0.05), which increased after exposure to hypoxia and hypoxia with exercise (p < 0.001). Hypoxia significantly decreased baseline transforming growth factor-β (TGF-β) (p < 0.05) and had a significant effect on tumor necrosis factor-α level (TNF-α) (F = 4.9; p < 0.05).
Our study demonstrated that hypoxia combined with exercise reduces glycemia and may induce significant benefits in the prevention of diabetes cardiovascular complications.
体育活动是糖尿病治疗不可或缺的一部分。科学报告显示，低氧和运动对糖尿病患者的心血管和代谢变量具有有益影响。
本研究旨在评估常压低氧和运动对1型糖尿病患者血清促血管生成因子浓度和血糖的影响。
共有28名成年人（年龄30.4岁±9.7岁，患糖尿病12.1年±6.0年）以及健康个体参与了以下试验：常氧（Nor）和低氧（Hy）休息，以及Nor和Hy递增运动试验（Ex）（吸入氧分数=FIO2=15.2%）。本研究使用了相当于海拔约2500米高度的Altitude Trainer Hypoxico系统（HYP - 123低氧发生器，德国柏林LOWOXYGEN Technology GmbH公司）。运动试验在Excalibur Sport型自行车测力计（荷兰格罗宁根Lode B.V.公司）上进行。在休息时以及对两种运动方案的反应中测量心肺变量、血糖、血管生成和血液学指标。
目前的数据证实，1型糖尿病患者表现出良好的有氧能力和身体素质。NorEx和HyEx导致血清葡萄糖浓度显著降低（p<0.05与p<0.01）。与健康成年人相比，糖尿病患者的基线低氧诱导因子-1α水平更高（p<0.05），在暴露于低氧和低氧运动后升高（p<0.001）。低氧显著降低基线转化生长因子-β（TGF-β）（p<0.05），并对肿瘤坏死因子-α水平（TNF-α）有显著影响（F=4.9；p<0.05）。
我们的研究表明，低氧与运动相结合可降低血糖，并可能在预防糖尿病心血管并发症方面带来显著益处。
