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创伤死亡的当代时间模式。

The contemporary timing of trauma deaths.

机构信息

From the Division of Trauma and Acute Care Surgery (K.I., M.S., D.G., A.S., K.M., D.C., D.D.), Los Angeles County and University of Southern California; and Preventative Medicine (N.B.) Keck School of Medicine, Los Angeles, California.

出版信息

J Trauma Acute Care Surg. 2018 Jun;84(6):893-899. doi: 10.1097/TA.0000000000001882.

Abstract

BACKGROUND

The distribution of trauma deaths was classically described as trimodal. With advances in both technology and trauma systems, this was reevaluated and found to be bimodal in the early 2000s. Over the last decade there have been continued improvements in trauma and intensive care unit (ICU) care, related to damage control techniques and evidence based ICU pathways. A better understanding of the distribution of trauma deaths may be used to improve trauma systems. This study aimed to evaluate the contemporary distribution of trauma deaths after the widespread implementation of modern trauma and critical care principles.

METHODS

This study included patients entered in the NTDB from 2008 to 2014. For dead patients, hospital length of stay was equated to time until death. Additional data was collected to include demographics, mechanism of injury, Injury Severity Score, and Abbreviated Injury Scale score. Histograms were plotted to demonstrate peaks in deaths. Survival analysis was performed with Kaplan-Meier curves and Gehan-Breslow generalized Wilcoxon tests.

RESULTS

4,185,009 patients were analyzed. Thirty-four percent of all deaths occurred within the first 24 hours of admission. The factors most associated with death in the first 24 hours were severe abdominal trauma (73%), penetrating trauma (55%), and severe extremity trauma (58%). Among patients with penetrating trauma and an abdominal Abbreviated Injury Scale score of 4 or higher, 83% of deaths occurred within 24 hours. When plotted, the distribution of deaths was seen to fall rapidly after the first 24 hours and continued to be flat for 30 days in all subgroups analyzed.

CONCLUSION

In this study, the distribution of trauma deaths no longer appears to be trimodal. This may reflect advances in trauma and ICU care, and the widespread adaption of damage control principles. Early deaths, however, remains a significant challenge, specifically from non-compressible abdominal hemorrhage and extremity trauma. Primary prevention and early hemorrhage control must continue to be a focus of research and trauma systems.

LEVEL OF EVIDENCE

Epidemiologic, level IV.

摘要

背景

创伤死亡的分布曾被经典地描述为三峰模式。随着技术和创伤系统的进步,这种模式在 21 世纪初被重新评估为双峰模式。在过去的十年中,由于损伤控制技术和基于证据的 ICU 路径的应用,创伤和重症监护病房(ICU)的治疗得到了持续改善。更好地了解创伤死亡的分布情况,可能有助于改善创伤系统。本研究旨在评估现代创伤和重症监护原则广泛实施后创伤死亡的当代分布情况。

方法

本研究纳入了 2008 年至 2014 年期间纳入 NTDB 的患者。对于死亡患者,将住院时间等同于死亡时间。收集了其他数据,包括人口统计学、损伤机制、损伤严重程度评分和简明损伤评分。绘制直方图以显示死亡高峰。采用 Kaplan-Meier 曲线和 Gehan-Breslow 广义 Wilcoxon 检验进行生存分析。

结果

共分析了 4185009 名患者。34%的死亡发生在入院后的 24 小时内。在 24 小时内死亡的主要因素是严重腹部创伤(73%)、穿透性创伤(55%)和严重四肢创伤(58%)。对于有穿透性创伤且腹部简明损伤评分≥4 的患者,83%的死亡发生在 24 小时内。绘制分布图后发现,所有亚组在 24 小时后死亡分布迅速下降,并在 30 天内持续平坦。

结论

在本研究中,创伤死亡的分布似乎不再呈三峰模式。这可能反映了创伤和 ICU 治疗的进步,以及损伤控制原则的广泛应用。然而,早期死亡仍然是一个重大挑战,特别是由不可压缩性腹部出血和四肢创伤引起的死亡。初级预防和早期出血控制必须继续成为研究和创伤系统的重点。

证据水平

流行病学,四级。

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