Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.
J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e169-e171. doi: 10.1093/jpids/piy021.
An 11-year-old immunocompetent girl presented with two and a half months of progressive right orbital cellulitis, which did not respond to multiple courses of antibiotics or prednisone. A panfungal polymerase chain reaction primer was positive for Saksenaea vasiformis, and she completed 5 months of oral posaconazole therapy after debridement. Saksenaea vasiformis is a rare cause of zygomycosis, and it typically causes skin and soft tissue infection in immunocompetent hosts, particularly after a traumatic injury. The diagnosis should be considered in cases with a protracted course that fail to respond to typical antibiotic therapy. Treatment includes surgical debridement, in additional to antifungal therapy with amphotericin B or posaconazole.
一位 11 岁免疫功能正常的女孩出现了两个半月的右眼眶蜂窝织炎，尽管使用了多种抗生素和泼尼松治疗，但仍未得到缓解。Panfungal polymerase chain reaction primer 对 Saksenaea vasiformis 呈阳性反应，在清创后她接受了 5 个月的口服泊沙康唑治疗。Saksenaea vasiformis 是一种罕见的接合菌病病原体，通常在免疫功能正常的宿主中引起皮肤和软组织感染，特别是在创伤后。对于那些病程迁延且对典型抗生素治疗无反应的病例，应考虑诊断该病。治疗包括手术清创，以及使用两性霉素 B 或泊沙康唑进行抗真菌治疗。
