First Department of General Surgery, General Hospital of Attica "KAT", 141 Oropou Str., 14232, Athens, Greece.
Microbiology Department, General Hospital of Attica "KAT", Athens, Greece.
Mycopathologia. 2019 Feb;184(1):159-167. doi: 10.1007/s11046-018-0249-6. Epub 2018 Jul 30.
Saksenaea vasiformis is one of the numerous fungi of the Order Mucorales. Rapid progression and invasion of neighboring tissues are the most characteristic features of S. vasiformis mucormycosis.
The objective of this review is the management of this type of infections.
Case report and literature review.
A 62-year old woman, without a history of immunocompromisation, developed a localized cutaneous infection at her right thigh. No trauma, skin laceration or insect bite was reported at the side of infection. The initial treatment was surgical debridements and intravenous administration of amphotericin B/posaconazole. In order to avoid the further rapid progression of the infection and save her life, it was decided to proceed to amputation of the patient's right leg. This is the first case of S. vasiformis cutaneous infection in an immunocompetent patient, in Greece.
Early diagnosis of S. vasiformis mucormycosis is of paramount importance. Clinical suspicion, based on the rapid progression of the infection and on the medical history of the patient, is sufficient to start antifungal treatment. Broad, aggressive, and repeated surgical debridement of the infection site together with systemic antifungal agents administration is the key point for successful treatment.
Saksenaea vasiformis 是毛霉目众多真菌中的一种。Saksenaea vasiformis 毛霉病的最特征性特征是快速进展和侵袭邻近组织。
本综述的目的是管理这种类型的感染。
病例报告和文献复习。
一名 62 岁女性，无免疫功能低下史，右大腿出现局部皮肤感染。在感染部位无外伤、皮肤裂伤或昆虫叮咬的报告。最初的治疗是手术清创和静脉注射两性霉素 B/泊沙康唑。为了避免感染的进一步快速进展并挽救她的生命，决定对患者的右腿进行截肢。这是希腊首例免疫功能正常患者的 Saksenaea vasiformis 皮肤感染病例。
早期诊断 Saksenaea vasiformis 毛霉病至关重要。基于感染的快速进展和患者的病史，临床怀疑足以开始抗真菌治疗。广泛、积极和反复的感染部位手术清创加上全身抗真菌药物的应用是成功治疗的关键。
