Packer Rebecca A, Rossmeisl John H, Kent Michael S, Griffin John F, Mazcko Christina, LeBlanc Amy K
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523-1678.
Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061.
Vet Radiol Ultrasound. 2018 May;59(3):261-271. doi: 10.1111/vru.12608. Epub 2018 Mar 9.
The National Cancer Institute Comparative Brain Tumor Consortium, Patient Outcomes Working Group, propose a consensus document in support of standardized magnetic resonance imaging protocols for canine brain tumor clinical trials. The intent of this manuscript is to address the widely acknowledged need to ensure canine brain tumor imaging protocols are relevant and have sufficient equivalency to translate to human studies such that: (1) multi-institutional studies can be performed with minimal inter-institutional variation, and (2) imaging protocols are consistent with human consensus recommendations to permit reliable translation of imaging data to human clinical trials. Consensus recommendations include pre- and postcontrast three-dimensional T1-weighted images, T2-weighted turbo spin echo in all three planes, T2*-weighted gradient recalled echo, T2-weighted fluid attenuated inversion recovery, and diffusion weighted imaging/diffusion tensor imaging in transverse plane; field of view of ≤150 mm; slice thickness of ≤2 mm, matrix ≥ 256 for two-dimensional images, and 150 or 256 for three-dimensional images.
美国国立癌症研究所比较脑肿瘤联盟患者预后工作组提出了一份共识文件，以支持用于犬脑肿瘤临床试验的标准化磁共振成像方案。本手稿的目的是满足广泛认可的需求，即确保犬脑肿瘤成像方案具有相关性且与人类研究具有足够的等效性，以便：（1）多机构研究能够在机构间差异最小的情况下进行，以及（2）成像方案与人类共识建议一致，从而能够将成像数据可靠地转化为人类临床试验。共识建议包括对比剂前和对比剂后的三维T1加权图像、三个平面上的T2加权快速自旋回波、T2*加权梯度回波、T2加权液体衰减反转恢复以及横断面的扩散加权成像/扩散张量成像；视野≤150毫米；层厚≤2毫米，二维图像的矩阵≥256，三维图像的矩阵为150或256。
