Levy Daniel A, Mika Rotem, Radzyminski Cecilia, Ben-Zvi Shir, Tibon Roni
Baruch Ivcher School of Psychology, The Interdisciplinary Center, Herzliya, Israel.
Department of Psychology, Tel-Aviv University, Tel Aviv, Israel.
Neurobiol Learn Mem. 2018 Apr;150:75-83. doi: 10.1016/j.nlm.2018.03.004. Epub 2018 Mar 6.
In studies of behavioral reconsolidation interference, reactivation of a consolidated memory using some form of reminder is followed by the presentation of new information that can cause interference with that memory. Under these conditions, the interference not only impairs retrieval by indirect processes such as cue interference, but supposedly disrupts the original memory trace directly. Almost all studies of behavioral reconsolidation interference in episodic memory in humans have employed between-subjects paradigms, and deduced reminder effects from intrusion errors. Such studies might introduce confounds arising, for example, from differences in retrieval strategies engendered by the pre-test treatments. We therefore set out to examine whether behavioral reconsolidation interference in episodic memory might be demonstrated within-subjects and by direct memory strength rather than intrusion errors. In three separate experiments, we attempted to disrupt reconsolidation of episodic object-picture memory using a reminder + retroactive interference manipulation. We applied the manipulation over three consecutive days, using a forced-choice recognition test without intrusions from interfering learning, keeping all other study and test parameters constant. No effects of reminder-potentiated interference were observed for measures of accuracy, response times, subjective expressions of recollection, or levels of confidence, as substantiated by Bayesian analyses. These results highlight the difficulty of observing clear behavioral reconsolidation interference effects within-subjects in human episodic memory, and provide some indications of what might be boundary conditions for its demonstration.
在行为性再巩固干扰的研究中，使用某种形式的提示重新激活巩固的记忆之后，会呈现可能对该记忆产生干扰的新信息。在这些条件下，干扰不仅会通过线索干扰等间接过程损害提取，而且据推测会直接破坏原始记忆痕迹。几乎所有关于人类情景记忆中行为性再巩固干扰的研究都采用了被试间范式，并从侵入性错误中推断提示效应。此类研究可能会引入混淆因素，例如，由预测试处理产生的提取策略差异。因此，我们着手研究情景记忆中的行为性再巩固干扰是否可以在被试内得到证明，以及是否可以通过直接记忆强度而非侵入性错误来证明。在三个独立的实验中，我们试图使用提示+追溯干扰操作来破坏情景物体-图片记忆的再巩固。我们在连续三天内应用该操作，使用无干扰学习侵入的强制选择识别测试，保持所有其他学习和测试参数不变。贝叶斯分析证实，在准确性、反应时间、回忆的主观表达或信心水平的测量中，未观察到提示增强干扰的影响。这些结果凸显了在人类情景记忆中观察被试内清晰的行为性再巩固干扰效应的困难，并为其证明的可能边界条件提供了一些线索。
