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非糖尿病和糖尿病母亲及其婴儿体内的糖化血红蛋白和糖化白蛋白

Glycosylated haemoglobin and glycosylated albumin in non-diabetic and diabetic mothers, and their babies.

作者信息

John W G, Webb A M, Jones A E

出版信息

Diabet Med. 1985 Mar;2(2):103-4. doi: 10.1111/j.1464-5491.1985.tb00609.x.

DOI:10.1111/j.1464-5491.1985.tb00609.x
PMID:2952391
Abstract

Glycosylated haemoglobin (GHb), glycosylated albumin (GAlb), and blood glucose were measured from 283 non-diabetic, 7 insulin-dependent diabetic, and 5 gestational diabetic mothers, and in the cord blood of their babies. Significant correlation was found between mother and baby for GHb (r = 0.31) and GAlb (r = 0.42). However, GHb, GAlb and glucose concentration were significantly higher in maternal blood compared to cord blood (p less than 0.001). Only GAlb showed any difference between a pregnant and a non-pregnant population (p less than 0.001). All three parameters were significantly higher in the diabetic mothers compared to the non-diabetic mothers (p less than 0.001). No difference was found between the levels of GHb and GAlb in babies from these two groups. There was no difference in the level of GHb between gestational and insulin-dependent mothers although the latter showed a significantly higher blood glucose (p less than 0.05).

摘要

对283名非糖尿病母亲、7名胰岛素依赖型糖尿病母亲和5名妊娠糖尿病母亲及其婴儿的脐带血进行了糖化血红蛋白(GHb)、糖化白蛋白(GAlb)和血糖检测。发现母亲与婴儿的GHb(r = 0.31)和GAlb(r = 0.42)之间存在显著相关性。然而,与脐带血相比,母亲血液中的GHb、GAlb和葡萄糖浓度显著更高(p小于0.001)。只有GAlb在孕妇和非孕妇群体之间存在差异(p小于0.001)。与非糖尿病母亲相比,糖尿病母亲的所有三个参数均显著更高(p小于0.001)。这两组婴儿的GHb和GAlb水平没有差异。妊娠糖尿病母亲和胰岛素依赖型糖尿病母亲的GHb水平没有差异,尽管后者的血糖显著更高(p小于0.05)。

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