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Comparative in vitro activity of A-56268 (TE-031), a new macrolide antibiotic.

作者信息

Hodinka R L, Jack-Wait K, Gilligan P H

出版信息

Eur J Clin Microbiol. 1987 Feb;6(1):103-8. doi: 10.1007/BF02097212.

DOI:10.1007/BF02097212
PMID:2952499
Abstract

The in vitro activity of A-56268 (TE-031) was determined by either standard agar dilution or macrobroth tube dilution and compared with erythromycin and other antimicrobial agents against 329 clinical aerobic and anaerobic bacterial isolates. A-56268 showed good to excellent in vitro activity against methicillin-sensitive Staphylococcus aureus, Neisseria meningitidis, and most anaerobes tested with the exception of Bacteroides fragilis isolates. A-56268 had relatively poor activity against coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus. Except for Haemophilus spp., the activity of A-56268 was similar to or more potent than erythromycin against all other isolates tested. A-56268 did not have significant bactericidal activity against any of the isolates examined.

摘要

相似文献

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2
Comparative in-vitro activity of A-56268 (TE-031), a new macrolide antibiotic.新型大环内酯类抗生素A-56268(TE-031)的体外活性比较
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本文引用的文献

1
Method of reliable determination of minimal lethal antibiotic concentrations.可靠测定最低致死抗生素浓度的方法。
Antimicrob Agents Chemother. 1980 Nov;18(5):699-708. doi: 10.1128/AAC.18.5.699.
Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):798-802. doi: 10.1007/BF01975054.
4
Comparative in vitro activity of clarithromycin. Spanish Collaborative Group.克拉霉素的体外活性比较。西班牙协作组。
Eur J Clin Microbiol Infect Dis. 1992 Sep;11(9):856-66. doi: 10.1007/BF01960892.