新型大环内酯类药物RU 28965与红霉素对需氧菌和厌氧菌活性的体外比较。
In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.
作者信息
Barlam T, Neu H C
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):529-31. doi: 10.1128/AAC.25.4.529.
Abstract
RU 28965, a novel macrolide antibiotic, inhibited most gram-positive species at concentrations similar to that of erythromycin but was not active, even at alkaline pH, against Pseudomonas spp. or members of the family Enterobacteriaceae. Staphylococci and streptococci resistant to erythromycin were resistant to RU 28965. RU 28965 inhibited Haemophilus influenzae, including a number of beta-lactamase, ampicillin-resistant isolates, and Neisseria meningitidis and Neisseria gonorrhoeae at concentrations similar to those of erythromycin. Against anaerobic species, Bacteroides fragilis and Clostridia and Fusobacterium spp., RU 28965 was less active than erythromycin, but its activity against Campylobacter and Legionella spp. was similar to that of erythromycin.
摘要
新型大环内酯类抗生素RU 28965对大多数革兰氏阳性菌的抑制浓度与红霉素相似，但即使在碱性pH条件下，对铜绿假单胞菌或肠杆菌科细菌也无活性。对红霉素耐药的葡萄球菌和链球菌对RU 28965也耐药。RU 28965对流感嗜血杆菌（包括一些产β-内酰胺酶、耐氨苄西林的菌株）、脑膜炎奈瑟菌和淋病奈瑟菌的抑制浓度与红霉素相似。对于厌氧菌，如脆弱拟杆菌、梭菌属和梭杆菌属，RU 28965的活性低于红霉素，但其对弯曲杆菌属和军团菌属的活性与红霉素相似。
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Antimicrob Agents Chemother. 1981 Dec;20(6):793-9. doi: 10.1128/AAC.20.6.793.
3
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4
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