Eliopoulos G M, Reiszner E, Ferraro M J, Moellering R C
Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts.
J Antimicrob Chemother. 1987 Nov;20(5):671-5. doi: 10.1093/jac/20.5.671.
The comparative in-vitro activity of A-56268 (TE-031), a new semisynthetic macrolide antibiotic, was assessed against approximately 400 bacterial isolates. The new drug demonstrated excellent activity against penicillin-susceptible streptococci (MIC90s less than or equal to 0.06 mg/l) and methicillin-susceptible staphylococci (MIC90 = 0.25 mg/l). Among other Gram-positive organisms tested, a significant number were resistant to A-56268 as well as to erythromycin and clindamycin. A-56268 was at least as active as erythromycin against Pasteurella multocida and Campylobacter jejuni, but was more active than erythromycin against Legionella spp. (MIC90 less than or equal to 0.06 mg/l), Bacteroides fragilis (MIC90 = 4 mg/l) and Bact. melaninogenicus (MIC90 less than or equal to 0.125 mg/l). Activity of A-56268 was pH dependent (more active at pH 7 than at pH 6) and was moderately affected by inoculum size. The drug was bactericidal against two strains of Streptococcus pyogenes tested, but exerted a bacteriostatic effect against Staphylococcus aureus and Str. faecalis.
对一种新型半合成大环内酯类抗生素A-56268（TE-031）的体外比较活性进行了评估，受试细菌分离株约400株。该新药对青霉素敏感的链球菌（MIC90≤0.06mg/L）和甲氧西林敏感的葡萄球菌（MIC90 = 0.25mg/L）显示出优异活性。在测试的其他革兰氏阳性菌中，有相当数量的菌株对A-56268以及红霉素和克林霉素耐药。A-56268对多杀巴斯德菌和空肠弯曲菌的活性至少与红霉素相当，但对嗜肺军团菌（MIC90≤0.06mg/L）、脆弱拟杆菌（MIC90 = 4mg/L）和产黑素类杆菌（MIC90≤0.125mg/L）的活性比红霉素更强。A-56268的活性与pH有关（在pH 7时比在pH 6时活性更强），且受接种量的影响适中。该药物对测试的两株化脓性链球菌具有杀菌作用，但对金黄色葡萄球菌和粪肠球菌发挥抑菌作用。
