Benson C, Segreti J, Kessler H, Hines D, Goodman L, Kaplan R, Trenholme G
Eur J Clin Microbiol. 1987 Apr;6(2):173-8. doi: 10.1007/BF02018203.
The in vitro activity of A-56268 (TE-031) was determined and compared with that of 13 antibiotics against 401 gram-positive and gram-negative bacteria and 11 strains of Chlamydia trachomatis. A-56268 was very active against methicillin-susceptible Staphylococcus aureus and Neisseria gonorrhoeae, and was among the most active of the agents tested against Listeria monocytogenes, streptococci and Chlamydia trachomatis. It was moderately active against Haemophilus spp., Vibrio spp., Campylobacter jejuni and Campylobacter fetus subsp. fetus. It was inactive against enterococci, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Campylobacter coli, Salmonella spp., Shigella spp. and Yersinia enterocolitica. A-56268 was not consistently bactericidal or more active than erythromycin for any organism except Chlamydia trachomatis.
测定了A-56268（TE-031）的体外活性，并将其与13种抗生素针对401株革兰氏阳性菌和革兰氏阴性菌以及11株沙眼衣原体的活性进行了比较。A-56268对甲氧西林敏感金黄色葡萄球菌和淋病奈瑟菌具有很强的活性，并且是针对单核细胞增生李斯特菌、链球菌和沙眼衣原体测试的药物中活性最强的之一。它对嗜血杆菌属、弧菌属、空肠弯曲菌和胎儿弯曲菌胎儿亚种具有中等活性。它对肠球菌、耐甲氧西林金黄色葡萄球菌、表皮葡萄球菌、结肠弯曲菌、沙门氏菌属、志贺氏菌属和小肠结肠炎耶尔森菌无活性。除沙眼衣原体外，A-56268对任何生物体都没有持续的杀菌作用，也不比红霉素更具活性。
