Institute of Materials Research and Engineering, A*STAR, 2 Fusionopolis Way, Innovis, Singapore 138634, Singapore.
Institute of High Performance Computing, A*STAR, 1 Fusionopolis Way, Connexis, Singapore 138632, Singapore; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:151-172. doi: 10.1016/j.msec.2018.01.007. Epub 2018 Jan 31.
The present review will introduce the basic concepts of silk-based electronics/optoelectronics including the latest technological advances on the use of silk fibroin in combination with other functional components, with an emphasis on improving the performance of next-generation silk-based materials. It also highlights the patterning of silk fibroin to produce micro/nano-scale features, as well as the functionalization of silk fibroin to impart antimicrobial (i.e. antibacterial) properties. Silk-based bioelectronics have great potential for advanced or futuristic bio-applications including e-skins, e-bandages, biosensors, wearable displays, implantable devices, artificial muscles, etc. Notably, silk-based organic field-effect transistors have highly promising applications in e-skins and biosensors; silk-based electrodes/antennas are used for in vivo bioanalysis or sensing purpose (e.g., measurement of neurotransmitter such as dopamine) in addition to their use as food sensors; silk-based diodes can be applied as light sources for wound healing or tissue engineering, e.g., in cutaneous wound closure or induction of photothrombosis of corneal neovascularization; silk-based actuators have promising applications as artificial muscles; whereas silk-based memristors have exciting applications as logic or synaptic network for realizing e-skins or bionic brains.
本综述将介绍基于丝的电子/光电的基本概念，包括最新的利用丝素与其他功能组件结合的技术进展，重点是提高下一代基于丝的材料的性能。它还强调了丝素的图案化以产生微/纳米尺度的特征，以及丝素的功能化以赋予抗菌（例如，抗细菌）特性。基于丝的生物电子学在先进或未来的生物应用方面具有巨大的潜力，包括电子皮肤、电子绷带、生物传感器、可穿戴显示器、可植入设备、人造肌肉等。值得注意的是，基于丝的有机场效应晶体管在电子皮肤和生物传感器中有非常有前景的应用；基于丝的电极/天线用于体内生物分析或传感目的（例如，测量神经递质如多巴胺），除了用作食物传感器之外；基于丝的二极管可用作光源用于伤口愈合或组织工程，例如，在皮肤伤口闭合或诱导角膜新生血管的光血栓形成；基于丝的致动器在作为人造肌肉方面具有广阔的应用前景；而基于丝的忆阻器在实现电子皮肤或仿生大脑的逻辑或突触网络方面具有令人兴奋的应用。
