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幼儿腺样体手术中的局部止血剂;一项前瞻性随机对照试验。

Topical blood stopper agents during adenoid surgery in young children; a prospective randomized controlled trial.

作者信息

Abdallah Randa A, Ragab Sameh M, Hassanin Maher Z

机构信息

AL Azhar University Hospitals, Cairo, Egypt.

Taiba Hospital, Bayan, Kuwait.

出版信息

Eur Arch Otorhinolaryngol. 2018 May;275(5):1157-1163. doi: 10.1007/s00405-018-4929-0. Epub 2018 Mar 10.

DOI:10.1007/s00405-018-4929-0
PMID:29525823
Abstract

OBJECTIVE

To investigate the safety and efficacy of two topical blood stopper modulators; Ankaferd blood stopper (ABS) and feracrylum 1% solution (FS) during adenoid surgery.

STUDY DESIGN

Prospective randomized trial.

METHODS

Two hundred and twenty five consecutive pediatric adenoid patients aged from 9 months to 2 years old were studied. Patients were randomly allocated into two haemostatic groups; (ABS, FS) and normal saline (control group).

RESULTS

ABS and FS groups showed a significantly less intra operative blood loss (16.4 ± 2.6/22 ± 6.2), operative time (9.31 ± 1.9/11.2 ± 1.6 min), use of cautery (10.6/25.3%), postoperative analgesics (3 ± 1.1/3.8 ± 1.2), duration to return normal diet (2.4 ± 1.2/3.9 ± 0.9) and operating theatre cost (233 ± 48$ and 279 ± 40$) than the control group.

CONCLUSION

AFS and FS are easy, safe, and reliable topical haemostatic modulators that could be used in adenoid surgery.

摘要

目的

研究两种局部止血调节剂安卡福得止血剂(ABS)和1%氰基丙烯酸正丁酯溶液(FS)在腺样体手术中的安全性和有效性。

研究设计

前瞻性随机试验。

方法

对225例年龄在9个月至2岁的连续性小儿腺样体患者进行研究。患者被随机分为两个止血组,即ABS组、FS组和生理盐水组(对照组)。

结果

与对照组相比,ABS组和FS组术中失血量(16.4±2.6/22±6.2)、手术时间(9.31±1.9/11.2±1.6分钟)、烧灼止血的使用(10.6/25.3%)、术后镇痛药的使用(3±1.1/3.8±1.2)、恢复正常饮食的时间(2.4±1.2/3.9±0.9)以及手术室费用(233±48美元和279±40美元)均显著减少。

结论

AFS和FS是简便、安全且可靠的局部止血调节剂,可用于腺样体手术。

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本文引用的文献

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A prospective comparison of topical feracrylum citrate versus adrenaline as haemostatic agent in hypospadias surgery in children.儿童尿道下裂手术中局部应用枸橼酸铁丙烯酯与肾上腺素作为止血剂的前瞻性比较。
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Successful management of bleeding after dental procedures with application of blood stopper: a single center prospective trial.应用止血剂成功管理牙科手术后出血:一项单中心前瞻性试验
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Achieving hemostasis with topical hemostats: making clinically and economically appropriate decisions in the surgical and trauma settings.
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The hemostatic efficacy of Ankaferd Blood Stopper in adenoidectomy.安卡非德止血剂在腺样体切除术中的止血效果。
Int J Pediatr Otorhinolaryngol. 2011 Oct;75(10):1292-5. doi: 10.1016/j.ijporl.2011.07.014. Epub 2011 Aug 2.
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Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy.安卡菲德止血剂用于扁桃体切除儿童的前瞻性对照临床试验。
Int J Pediatr Otorhinolaryngol. 2009 Dec;73(12):1742-5. doi: 10.1016/j.ijporl.2009.09.029.
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Oral systemic administration of Ankaferd blood stopper has no short-term toxicity in an in vivo rabbit experimental model.口服安可血塞停在兔体内实验模型中无短期毒性。
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Updated systematic review of tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea/hypopnea syndrome.扁桃体切除术和腺样体切除术治疗小儿阻塞性睡眠呼吸暂停/低通气综合征的最新系统评价
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Electrocautery adenoidectomy outcomes: a meta-analysis.
Otolaryngol Head Neck Surg. 2009 Feb;140(2):148-53. doi: 10.1016/j.otohns.2008.11.030.
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