Trad S, Bonnet C, Monnet D
Service de médecine interne, hôpital Ambroise-Paré, 92104 Boulogne-Billancourt, France.
Service d'ophtalmologie, Inserm U1016, CNRS UMR8104, hôpital Cochin, université Paris Descartes, 75014 Paris, France.
Rev Med Interne. 2018 Sep;39(9):699-710. doi: 10.1016/j.revmed.2018.02.017. Epub 2018 Mar 9.
Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this drug-induced toxicity yearly in the course of an unexplained ocular injury, before its damage become irreversible, (ii) to be able to recognize induced paradoxical ocular inflammation, mimicking an inflammatory pathology flare-up, especially in patient under anti-TNF regimen and (iii) to propose a more in-depth knowledge on recently described ocular toxicities from targeted cancer therapy, mainly the tyrosine kinase inhibitors.
眼部药物副作用多种多样,可影响眼睛的所有结构。本综述的目的是帮助临床医生:(i)在不明原因的眼部损伤过程中,每年在药物诱导的毒性损害变得不可逆转之前唤起对此的认识;(ii)能够识别诱发的矛盾性眼部炎症,这种炎症类似于炎症性病变的突然发作,尤其是在接受抗TNF治疗方案的患者中;以及(iii)提供关于靶向癌症治疗最近描述的眼部毒性的更深入知识,主要是酪氨酸激酶抑制剂。