MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg, South Africa; Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, P.O. Box 1038, Johannesburg 2000, South Africa.
MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg, South Africa.
Diabetes Res Clin Pract. 2018 May;139:278-287. doi: 10.1016/j.diabres.2018.03.012. Epub 2018 Mar 8.
This study aimed to determine the prevalence of gestational diabetes mellitus (GDM) amongst black South African women, describe GDM-associated risk factors and clinical management, and evaluate the efficacy of the fasting plasma glucose reading in diagnosing GDM.
A cross-sectional screening study was performed. Pregnant women were recruited from the Chris Hani Baragwanath Academic Hospital in Johannesburg. A total of 1906 women underwent a two-hour 75 g oral glucose tolerance test at 24-28 weeks gestation. The World Health Organization's 2013 criteria were used to diagnose GDM.
A total of 174/1906 (9.1% (95% confidence interval (CI) 7.9, 10.5)) women were diagnosed with GDM. These women had significantly higher weights and body mass indexes (BMIs), were significantly older, of higher household socioeconomic status, more likely to report a family history of diabetes, and more likely to be diagnosed with anaemia than women without GDM. An age of ≥35 years, BMI ≥ 30 kg/m, and a family history of diabetes were significant risk factors. The fasting plasma glucose reading had a high sensitivity (83.3% (95% CI 77.0, 88.5)) in diagnosing GDM and 56.9% of the women with GDM were managed by diet therapy alone.
This is the largest GDM prevalence study in South Africa to date. A diagnosis of GDM increases the risk of both mother and child developing Type 2 diabetes which causes further health complications, decreases longevity, and burdens a country's healthcare system. Therefore, a GDM prevalence of 9.1% is concerning and warrants further discussion around current GDM screening policies.
本研究旨在确定南非黑人妇女中妊娠糖尿病(GDM)的患病率,描述 GDM 相关的危险因素和临床管理,并评估空腹血糖读数在诊断 GDM 中的效果。
进行了一项横断面筛查研究。在约翰内斯堡的克里斯·哈尼·巴哈加万纳斯塔德学术医院招募了孕妇。共有 1906 名妇女在 24-28 周妊娠时接受了 2 小时 75g 口服葡萄糖耐量试验。使用世界卫生组织 2013 年标准诊断 GDM。
共有 174/1906(9.1%(95%置信区间 7.9,10.5))名妇女被诊断为 GDM。这些妇女的体重和体重指数(BMI)明显更高,年龄更大,家庭社会经济地位更高,更有可能报告糖尿病家族史,并且更有可能被诊断为贫血,而非无 GDM 的妇女。年龄≥35 岁、BMI≥30kg/m2 和糖尿病家族史是显著的危险因素。空腹血糖读数在诊断 GDM 方面具有较高的灵敏度(83.3%(95%置信区间 77.0,88.5)),56.9%的 GDM 妇女仅通过饮食疗法进行管理。
这是迄今为止南非最大的 GDM 患病率研究。GDM 的诊断增加了母亲和孩子患 2 型糖尿病的风险,这会导致进一步的健康并发症,降低寿命,并给国家的医疗保健系统带来负担。因此,9.1%的 GDM 患病率令人担忧,需要进一步讨论当前的 GDM 筛查政策。