Fulford D E, Rutherford R B
J Leukoc Biol. 1987 Apr;41(4):363-6. doi: 10.1002/jlb.41.4.363.
Particle-bound C3b stimulated enhanced release of prostaglandin E and thromboxane B2 (TxB2) from human peripheral blood monocytes in vitro. Particle-bound C3b stimulation was correlated to the ability of the particles to bind to the monocytes. Monocytes stimulated with particle-bound and fluid-phase C3b always released more TxB2 than PGE. These data suggest that ligation of the C3b receptor on human monocytes results in enhanced arachidonic acid metabolism.
颗粒结合的C3b在体外刺激人外周血单核细胞增强前列腺素E和血栓素B2（TxB2）的释放。颗粒结合的C3b刺激与颗粒结合单核细胞的能力相关。用颗粒结合的和液相的C3b刺激的单核细胞总是比PGE释放更多的TxB2。这些数据表明，人单核细胞上C3b受体的连接导致花生四烯酸代谢增强。
