Tallquist Michelle D
University of Hawaii at Manoa, Center for Cardiovascular Research, Department of Medicine.
Curr Opin Physiol. 2018 Feb;1:75-79. doi: 10.1016/j.cophys.2017.08.002. Epub 2017 Dec 13.
The cardiac fibroblast has essential roles in production and maintenance of extracellular matrix. While its role in maladaptive myocardial remodeling has been a focus of many studies, the cardiac fibroblast has become a topic of great interest as a contributor to heart physiology and as a therapeutic target. Recent reports are changing how we view and study the cardiac fibroblast by providing greater insights into fibroblast biology using refined techniques for fibroblast identification and manipulation. Here, we briefly summarize some of these fundamental recent findings.
心脏成纤维细胞在细胞外基质的产生和维持中起着至关重要的作用。虽然其在适应性不良心肌重塑中的作用一直是许多研究的重点，但心脏成纤维细胞作为心脏生理学的一个促成因素和治疗靶点，已成为一个备受关注的话题。最近的报告通过使用用于成纤维细胞鉴定和操作的精细技术，对成纤维细胞生物学有了更深入的了解，从而改变了我们对心脏成纤维细胞的看法和研究方式。在这里，我们简要总结一些近期的这些重要发现。
