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Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis.

作者信息

Varzideh Fahimeh, Kansakar Urna, Donkor Kwame, Wilson Scott, Jankauskas Stanislovas S, Mone Pasquale, Wang Xujun, Lombardi Angela, Santulli Gaetano

机构信息

Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States.

出版信息

Front Cardiovasc Med. 2022 Apr 13;9:863238. doi: 10.3389/fcvm.2022.863238. eCollection 2022.

DOI:10.3389/fcvm.2022.863238
PMID:35498051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043126/
Abstract

After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c3/9043126/b61a53b6ad73/fcvm-09-863238-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c3/9043126/b61a53b6ad73/fcvm-09-863238-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c3/9043126/b61a53b6ad73/fcvm-09-863238-g001.jpg

相似文献

[1]
Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis.

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[3]
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[10]
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[8]
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[10]
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本文引用的文献

[1]
Functional Role of microRNAs in Regulating Cardiomyocyte Death.

Cells. 2022-3-12

[2]
IP3 receptor orchestrates maladaptive vascular responses in heart failure.

J Clin Invest. 2022-2-15

[3]
Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure.

J Clin Invest. 2022-2-1

[4]
miR-21 in Human Cardiomyopathies.

Front Cardiovasc Med. 2021-10-27

[5]
Adding a "Notch" to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach.

Front Cell Dev Biol. 2021-8-30

[6]
Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications.

Noncoding RNA. 2021-7-7

[7]
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Nat Rev Drug Discov. 2021-8

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Damage-Associated Molecular Patterns Modulation by microRNA: Relevance on Immunogenic Cell Death and Cancer Treatment Outcome.

Cancers (Basel). 2021-5-24

[9]
Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction.

Front Cardiovasc Med. 2021-4-23

[10]
MicroRNAs in Acute ST Elevation Myocardial Infarction-A New Tool for Diagnosis and Prognosis: Therapeutic Implications.

Int J Mol Sci. 2021-4-30

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