心肌梗死后的心脏重塑：微小RNA对炎症和纤维化的功能作用
Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis.
作者信息
Varzideh Fahimeh, Kansakar Urna, Donkor Kwame, Wilson Scott, Jankauskas Stanislovas S, Mone Pasquale, Wang Xujun, Lombardi Angela, Santulli Gaetano
机构信息
Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States.
出版信息
Front Cardiovasc Med. 2022 Apr 13;9:863238. doi: 10.3389/fcvm.2022.863238. eCollection 2022.
After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.
缺血性损伤后，心脏会经历一个复杂的结构和功能重塑过程，该过程涉及多个步骤，包括炎症反应和纤维化反应。在本综述中，我们重点关注微小RNA在心肌梗死后炎症和纤维化调节中的作用。我们总结了探索微小RNA与炎症关键调节因子和成纤维细胞活化之间相互作用的最新研究，并讨论了这些快速发展领域中的最新发现，包括临床应用。
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