一种用于协同光热和基因治疗的基于黑磷纳米片的小干扰RNA递送系统。
A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy.
作者信息
Wang Huimeng, Zhong Lin, Liu Yang, Xu Xin, Xing Chao, Wang Min, Bai Shu-Meng, Lu Chun-Hua, Yang Huang-Hao
机构信息
Key Laboratory for Analytical Science of Food Safety and Biology of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China.
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China.
出版信息
Chem Commun (Camb). 2018 Mar 28;54(25):3142-3145. doi: 10.1039/c8cc00931g. Epub 2018 Mar 12.
Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.
通过小干扰RNA（siRNA）进行基因治疗已被证明是一种通过阻碍靶蛋白产生来治疗各种疾病的有前途的技术。然而，开发一种在运输siRNA时具有高效率且无明显副作用的递送系统仍然是一项挑战。在此，我们设计了一种基于聚乙烯亚胺功能化黑磷（BP）纳米片的新型生存素siRNA递送系统，该系统可通过沉默生存素表达来抑制肿瘤生长。结合BP纳米片的光热特性，所提出的递送系统对肿瘤显示出优异的治疗效果。因此，基于BP的递送系统将是未来临床应用中一种有前途的工具。
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