Chen Jing-Lun, Nong Guang-Min
Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar;20(3):236-242. doi: 10.7499/j.issn.1008-8830.2018.03.014.
Infectious diseases can be caused by multiple pathogens, which can produce specific immune response in human body. The immune response produced by T cells is cellular immunity, which plays an important role in the anti-infection process of human body, and can participate in immunological protection and cause immunopathology. The outcome of various infectious diseases is closely related to cellular immune function, especially the function of T cells. Jurkat cells belong to the human acute T lymphocyte leukemia cell line. Jurkat cell model can simulate the function T lymphocytes, so it is widely used in the in vitro studies of T cell signal transduction, cytokines, and receptor expression, and can provide reference and guidance for the treatment of various infectious diseases and the research on their pathogenesis. The Jurkat cell model has been widely used in the in vitro studies of viral diseases and atypical pathogens, but parasitic infection studies using the Jurkat cell model are still rare. This article reviews advances in the application of Jurkat cell model in the research on infectious diseases.
传染病可由多种病原体引起，这些病原体可在人体产生特异性免疫反应。T细胞产生的免疫反应为细胞免疫，其在人体抗感染过程中发挥重要作用，可参与免疫保护并引发免疫病理反应。各种传染病的转归与细胞免疫功能密切相关，尤其是T细胞的功能。Jurkat细胞属于人急性T淋巴细胞白血病细胞系。Jurkat细胞模型可模拟T淋巴细胞的功能，因此广泛应用于T细胞信号转导、细胞因子及受体表达的体外研究，可为各种传染病的治疗及其发病机制研究提供参考和指导。Jurkat细胞模型已广泛应用于病毒性疾病和非典型病原体的体外研究，但利用Jurkat细胞模型进行寄生虫感染研究仍较少见。本文综述了Jurkat细胞模型在传染病研究中的应用进展。
