Masucci M G
Karolinska Institute, Stockholm, Sweden.
Curr Opin Immunol. 1993 Oct;5(5):693-700. doi: 10.1016/0952-7915(93)90123-a.
Virally induced tumors provide the strongest case of host surveillance against neoplastic cells and their precursors. Human cancers associated with Epstein-Barr virus, hepatitis B virus, papilloma virus and human T cell leukemia virus infection are responsible for approximately 15-20% of the total incidence of cancer world-wide. Current work in each of these virus/tumor systems seeks to understand the mechanisms of viral action and to identify strategies of immune intervention that may allow us to prevent viral infection or to control its potentially life-threatening consequences.
病毒诱导的肿瘤为宿主对肿瘤细胞及其前体进行监测提供了最有力的例证。与爱泼斯坦-巴尔病毒、乙型肝炎病毒、乳头瘤病毒和人类T细胞白血病病毒感染相关的人类癌症约占全球癌症总发病率的15%-20%。目前在这些病毒/肿瘤系统中的每一项研究都致力于了解病毒作用的机制，并确定免疫干预策略，这些策略可能使我们能够预防病毒感染或控制其潜在的危及生命的后果。
