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一只猫的神经元蜡样脂褐质沉积症的磁共振成像结果

MRI findings of neuronal ceroid lipofuscinosis in a cat.

作者信息

White Crystal, Mortier Jeremy, Verin Ranieri, Maddox Thomas, Goncalves Rita, Sanchez-Masian Daniel

机构信息

Leahurst Small Animal Teaching Hospital, University of Liverpool, Merseyside, UK.

出版信息

JFMS Open Rep. 2018 Mar 5;4(1):2055116918757330. doi: 10.1177/2055116918757330. eCollection 2018 Jan-Jun.

DOI:10.1177/2055116918757330
PMID:29531776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5843104/
Abstract

CASE SUMMARY

A 2-year-old male domestic shorthair cat presented to the University of Liverpool Small Animal Teaching Hospital with a 2 week history of altered mentation, blindness and focal epileptic seizures. MRI examination revealed generalised cerebral and cerebellar atrophy, diffuse T2-weighted hyperintensity of the white matter and meningeal thickening. Neuronal ceroid lipofuscinosis was confirmed on post-mortem examination.

RELEVANCE AND NOVEL INFORMATION

This is the first report of the MRI findings of neuronal ceroid lipofuscinosis in a cat.

摘要

病例摘要

一只2岁的雄性家猫被送到利物浦大学小动物教学医院，有2周精神状态改变、失明和局灶性癫痫发作的病史。MRI检查显示大脑和小脑普遍萎缩，白质在T2加权像上呈弥漫性高信号，脑膜增厚。尸检确诊为神经元蜡样脂褐质沉积症。

相关性及新信息

这是关于猫神经元蜡样脂褐质沉积症MRI表现的首次报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/ea6a3366c283/10.1177_2055116918757330-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/70e21b6c286d/10.1177_2055116918757330-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/02853ef908e9/10.1177_2055116918757330-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/ea6a3366c283/10.1177_2055116918757330-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/70e21b6c286d/10.1177_2055116918757330-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/02853ef908e9/10.1177_2055116918757330-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a59/5843104/ea6a3366c283/10.1177_2055116918757330-fig3.jpg

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Neurobiol Dis. 2017 Dec;108:277-287. doi: 10.1016/j.nbd.2017.08.017. Epub 2017 Aug 30.
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Neuronal ceroid lipofuscinoses.神经元蜡样脂褐质沉积症
Epileptic Disord. 2016 Sep 1;18(S2):73-88. doi: 10.1684/epd.2016.0844.
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Magnetic resonance findings of the corpus callosum in canine and feline lysosomal storage diseases.犬猫溶酶体贮积病的胼胝体磁共振成像表现。
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Vet Pathol. 2014 Jul;51(4):796-804. doi: 10.1177/0300985813502818. Epub 2013 Sep 11.
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