Sycheva M V, Kartashova O L, Shchepitova N E, Safronov Al A
Antibiot Khimioter. 2016;61(7-8):27-32.
High resistance of enterococci to the currently used antibacterials, such as tetracycline, ciprofloxacin and ampicillin was observed. Streptomycin, gentamicin and vancomycin showed the highest activity against the clinical isolates of Enterococcus spp. Streptomycin and gentamicin showed the highest activity against the intestinal enterococci. The PCR revealed the presence of the genetic determinants of resistance to aminoglycosides, glycopeptides and tetracycline in the isolates. The comparison of the results of the bacteriological and genetic tests provided detection of fecal and clinical isolates of Enterococcus spp. possessing the genes of resistance to aminoglycosides and glycopeptides, still without the finally developed significant clinical resistance to the above antibacterials.
观察到肠球菌对目前使用的抗菌药物（如四环素、环丙沙星和氨苄西林）具有高度耐药性。链霉素、庆大霉素和万古霉素对肠球菌临床分离株显示出最高活性。链霉素和庆大霉素对肠道肠球菌显示出最高活性。聚合酶链反应（PCR）揭示了分离株中存在对氨基糖苷类、糖肽类和四环素耐药的遗传决定因素。细菌学和基因检测结果的比较提供了对具有氨基糖苷类和糖肽类耐药基因的肠球菌粪便和临床分离株的检测，这些分离株对上述抗菌药物仍未最终产生显著的临床耐药性。
