Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.
J Nat Med. 2019 Jan;73(1):146-153. doi: 10.1007/s11418-018-1255-1. Epub 2018 Oct 26.
Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from Citrus genus, and the NMR data of 17 is reported here for the first time. Moreover, inhibitory effects of all compounds on motility of mouse isolated intestine tissue were determined. As a result, 1, 4-8, and 11 displayed significant inhibitory effects on contraction tension.
从柑橘属果实的 70%乙醇-水提取物中分离得到三种新化合物，即柑橘素 A（1）、B（2）和 C（3），以及 22 种已知化合物（4-25）。通过光谱方法鉴定了它们的结构。在已知化合物中，14、15、17 和 23 首次从柑橘属中获得，17 的 NMR 数据也是首次报道。此外，还测定了所有化合物对小鼠离体肠组织运动的抑制作用。结果表明，1、4-8 和 11 对收缩张力显示出显著的抑制作用。
