Tian Meng-Yin, Bao Jie, Li Xin, Zhang Qian-Ru, Li Sha-Sha, Gan Mao-Luo, Wang Su-Juan
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2022 May;24(5):483-489. doi: 10.1080/10286020.2021.1939311. Epub 2021 Jun 30.
Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine () and demethoxyacrophylline (), as well as 11 known alkaloids (-) were isolated from the root bark of Turcz. The structures of and were established by detailed spectroscopic elucidation, such as 1 D & 2 D NMR and HRMS, etc. The unexpected autoracemization of was discussed based on the stereochemistry of reported dihydrofuroquinolines. Compounds exhibited moderate inhibitory activities against , , and with MICs 32-64 μg/ml, revealing the active principles of for treating skin diseases in its traditional usage.
从Turcz.的根皮中分离出两种新的呋喃喹啉生物碱，分别命名为1'-氧代异普拉替定（）和去甲氧基阿克罗非林（），以及11种已知生物碱（-）。通过详细的光谱解析，如1D和2D NMR以及HRMS等，确定了和的结构。基于报道的二氢呋喃喹啉的立体化学，讨论了意外的自消旋化现象。化合物对、和表现出中等抑制活性，MIC为32 - 64μg/ml，揭示了其在传统用途中治疗皮肤病的活性成分。
