Park Hyung Wook, Kim Hong-Lim, Park Yong Soo, Kim In-Beom
Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Integrative Research Support Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Exp Neurobiol. 2018 Feb;27(1):28-33. doi: 10.5607/en.2018.27.1.28. Epub 2018 Feb 2.
The retina is a highly specialised part of the brain responsible for visual processing. It is well-laminated; three layers containing five different types of neurons are compartmentalised by two synaptic layers. Among the retinal layers, the inner nuclear layer (INL) is composed of horizontal, bipolar, and amacrine cell types. Bipolar cells form one sublayer in the distal half of the IPL, while amacrine cells form another sublayer in the proximal half, without any border-like structure. Here, we report that a plexiform layer-like structure exists temporarily in the border between the bipolar and amacrine sublayers in the INL in the rat retina during retinal development. This transient intermediate plexiform layer (TIPL) appeared at postnatal day (PD) 7 and then disappeared around PD 12. Most apoptotic cells in the INL were found near the TIPL. These results suggest that the TIPL may contribute to the formation of sublayers and the cell number limit in the INL.
视网膜是大脑中负责视觉处理的高度特化部分。它具有良好的分层结构；包含五种不同类型神经元的三层结构由两个突触层分隔开来。在视网膜各层中，内核层（INL）由水平细胞、双极细胞和无长突细胞类型组成。双极细胞在 IPL 远端半部形成一个亚层，而无长突细胞在近端半部形成另一个亚层，没有任何边界样结构。在此，我们报告在大鼠视网膜发育过程中，内核层中双极细胞和无长突细胞亚层之间的边界处暂时存在一种丛状层样结构。这种短暂的中间丛状层（TIPL）在出生后第 7 天出现，然后在出生后第 12 天左右消失。在内核层中，大多数凋亡细胞位于 TIPL 附近。这些结果表明，TIPL 可能有助于内核层亚层的形成和细胞数量限制。
