Rocha Luís A, Sousa Rui A, Learmonth David A, Salgado António J
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal.
Front Pharmacol. 2018 Feb 27;9:164. doi: 10.3389/fphar.2018.00164. eCollection 2018.
Spinal cord injury (SCI) represents an extremely debilitating condition for which no efficacious treatment is available. One of the main contributors to the inhospitable environment found in SCI is the vascular disruption that happens at the moment of injury that compromises the blood-spinal cord barrier (BSCB) and triggers a cascade of events that includes infiltration of inflammatory cells, ischemia and intraparenchymal hemorrhage. Due to the unsatisfactory nature of revascularization following SCI, restoring vascular perfusion and the BSCB seems an interesting way of modulating the lesion environment into a regenerative phenotype, with a potential increase in functional recovery. Certain biomaterials possess interesting features to enhance SCI therapies, and in fact have been applied as angiogenic promoters in other pathologies. The present mini-review intends to highlight the contribution that biomaterials could make in the development of novel therapeutic solutions able to restore proper vascularization and the BSCB.
脊髓损伤（SCI）是一种极其使人衰弱的病症，目前尚无有效的治疗方法。SCI中出现的不利环境的主要促成因素之一是损伤时发生的血管破坏，这会损害血脊髓屏障（BSCB），并引发一系列事件，包括炎性细胞浸润、缺血和实质内出血。由于SCI后血管再生的效果不尽人意，恢复血管灌注和BSCB似乎是将损伤环境调节为再生表型的一种有趣方法，有可能增加功能恢复。某些生物材料具有增强SCI治疗效果的有趣特性，实际上已在其他病症中用作血管生成促进剂。本综述旨在强调生物材料在开发能够恢复适当血管化和BSCB的新型治疗方案中可能做出的贡献。
