Laboratorio de Citoarquitectura y Plasticidad Neuronal (LCPN), Instituto de Investigaciones Cardiológicas, ININCA-UBA-CONICET, Buenos Aires, Argentina.
Unidad de Reumatología, Hospital JM Ramos Mejía, Buenos Aires, Argentina.
Front Immunol. 2018 Feb 26;9:139. doi: 10.3389/fimmu.2018.00139. eCollection 2018.
Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) patients without conventional cardiovascular risk factors (CVRFs) are not available. This preliminary study focuses on cardiovascular risk in cutaneous psoriasis (CPs) and recent-onset PsA patients. Blood biochemistry (glucose, cholesterol, uric acid, lipid profile and apolipoprotein B) was analyzed using standard kits. Proatherogenic inflammation markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activators monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (sICAM-1), were determined by enzyme-linked immunosorbent assay. Ultrasound images allowed measuring carotid intima-media thickness (cIMT). Our study first shows an increase in cIMT, and in serum levels of sICAM-1 and CRP in recent-onset PsA patients not presenting conventional CVRFs over the non-medicated time-period, from disease diagnosis to the beginning of pharmacological treatment, compared with healthy subjects. The outcome highlights the importance of monitoring serum level of sICAM1, CRP, and cIMT, and the value of primary prevention in psoriatic patients even with no history of cardiovascular events.
针对无传统心血管风险因素（CVRFs）的新发银屑病关节炎（PsA）患者炎症负担的研究尚不多见。本初步研究聚焦于皮肤银屑病（CPs）和新发 PsA 患者的心血管风险。采用标准试剂盒分析了血液生化指标（血糖、胆固醇、尿酸、血脂和载脂蛋白 B）。通过酶联免疫吸附试验测定了前粥样硬化炎症标志物 C 反应蛋白（CRP）和白细胞介素-6（IL-6），以及内皮激活物单核细胞趋化蛋白-1（MCP-1）和可溶性细胞间黏附分子-1（sICAM-1）。超声图像可用于测量颈动脉内膜中层厚度（cIMT）。我们的研究首次表明，与健康受试者相比，在无传统 CVRFs 的新发 PsA 患者中，从疾病诊断到开始药物治疗的非药物治疗期间，cIMT 以及血清 sICAM-1 和 CRP 水平增加。该结果强调了监测血清 sICAM1、CRP 和 cIMT 水平的重要性，以及对即使无心血管事件史的银屑病患者进行一级预防的价值。
