Zabeen Bedowra, Balsa Ana Margarida, Islam Nasreen, Parveen Mukta, Nahar Jebun, Azad Kishwar
Department of Paediatrics and CDiC BIRDEM, Dhaka, Bangladesh.
Diabetes E Nutrição Do Centro Hospitalar Do Baixo Vouga, Aveiro, Portugal.
Indian J Endocrinol Metab. 2018 Jan-Feb;22(1):89-92. doi: 10.4103/ijem.IJEM_217_17.
Dyslipidemia and hyperglycemia are metabolic abnormalities commonly found in young patients with Type 1 diabetes mellitus (T1DM) and both increase the risk of cardiovascular disease.
This cross-sectional study was aimed to evaluate the pattern of dyslipidemia and its relationship with other risk factors in children and adolescents with T1DM. A total of 576 T1DM patients aged 10-18 years who attended Changing Diabetes in Children, a pediatric diabetes clinic in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders over 1 year period from July 2015 to June 2016 were included in this study.
The overall frequency of dyslipidemia was 65%. The high triglyceride, high cholesterol, high low-density lipoprotein (LDL) and low high-density lipoprotein were found in 50%, 66%, 75%, and 48%, respectively. Compared to patients without dyslipidemia, patients with dyslipidemia had significantly lower mean body mass index (kg/m) (18.4 [interquartile range; 16.2-21.4] vs. 19.5 [17.3-21.5] ( = 0.005)); significantly higher median fasting blood sugar (12.7 [9.9-15.2] vs. 10.6 [7.9-12.6] ( < 0.0001)) and higher median glycosylated hemoglobin (9.8 [8.4-11.8] vs. 7.9 [9.3-10.5] ( < 0.0001)). Hypertension was significantly higher in dyslipidemic patients (9.4% vs. 2.5% < 0.002).
More than half (65%) of our children and adolescents with T1DM had dyslipidemia, among them high LDL was the most common. These findings emphasize the screening of lipid profile in T1DM children and adolescents.
血脂异常和高血糖是1型糖尿病（T1DM）年轻患者中常见的代谢异常情况，二者均会增加心血管疾病风险。
本横断面研究旨在评估T1DM儿童和青少年血脂异常模式及其与其他风险因素的关系。2015年7月至2016年6月期间，共有576名年龄在10 - 18岁的T1DM患者参加了孟加拉国糖尿病、内分泌和代谢紊乱研究与康复研究所的儿科糖尿病诊所“儿童糖尿病改变计划”，这些患者被纳入本研究。
血脂异常的总体发生率为65%。高甘油三酯、高胆固醇、高低密度脂蛋白（LDL）和低高密度脂蛋白的发生率分别为50%、66%、75%和48%。与无血脂异常的患者相比，血脂异常患者的平均体重指数（kg/m）显著更低（18.4[四分位间距；16.2 - 21.4]对19.5[17.3 - 21.5]（P = 0.005））；空腹血糖中位数显著更高（12.7[9.9 - 15.2]对10.6[7.9 - 12.6]（P < 0.0001）），糖化血红蛋白中位数也更高（9.8[8.4 - 11.8]对7.9[9.3 - 10.5]（P < 0.0001））。血脂异常患者的高血压发生率显著更高（9.4%对2.5%，P < 0.002）。
我们研究中超过一半（65%）的T1DM儿童和青少年存在血脂异常，其中高LDL最为常见。这些发现强调了对T1DM儿童和青少年进行血脂谱筛查的重要性。
