Kim Shin-Hee, Jung In-Ah, Jeon Yeon Jin, Cho Won Kyoung, Cho Kyoung Soon, Park So Hyun, Jung Min Ho, Suh Byoung Kyu
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Pediatr Endocrinol Metab. 2014 Dec;19(4):191-6. doi: 10.6065/apem.2014.19.4.191. Epub 2014 Dec 31.
We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM).
This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis.
Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R (2)=0.156) and TG (P=0.005, R (2)=0.261).
A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.
我们旨在调查1型糖尿病（T1DM）青少年和青年的血脂谱及血糖控制情况。
这项横断面研究纳入了29名患有T1DM的韩国青年和青少年。中位年龄为17岁（范围10 - 25岁），其中18名（62.1%）为女性。我们比较了血脂异常患者和无血脂异常患者的血脂谱。通过线性回归分析确定糖化血红蛋白（HbA1c）与血脂谱（总胆固醇[TC]、低密度脂蛋白胆固醇[LDL-C]、高密度脂蛋白胆固醇[HDL-C]和甘油三酯[TG]）之间的相关性。
在29例T1DM患者中，11例（37.9%）因以下血脂异常被归类为血脂异常：8例患者TC≥200 mg/dL，4例患者LDL-C≥130 mg/dL，2例患者TG≥150 mg/dL，2例患者HDL-C≤35 mg/dL。与无血脂异常的患者相比，血脂异常的患者更有可能具有较高的HbA1c值（中位数10.6%；范围7.5% - 12.3% vs.中位数8.0%；范围6.6% - 10.0%；P = 0.002）和较高的体重指数z评分（中位数0.7；范围 - 0.57至2.6 vs.中位数 - 0.4；范围 - 2.5至2.2；P = 0.02）。HbA1c水平与TC（P = 0.03，R(2)=0.156）和TG（P = 0.005，R(2)=0.261）呈正相关。
相当一部分患有T1DM的青少年和青年存在血脂异常。我们发现这些患者血糖控制不佳与血脂谱不良之间存在相关性。
