Tayyem Reema, Nawaiseh Hala, Zakarneh Sara Basem, Khial Yasmen, Allehdan Sabika
Department of Human Nutrition, College of Health Science, Qatar University, Doha, Qatar.
Department of Nutrition & Food Technology, Faculty of Agriculture, The University of Jordan, Amman, 11942, Jordan.
Adolesc Health Med Ther. 2024 Mar 19;15:31-43. doi: 10.2147/AHMT.S439046. eCollection 2024.
Dyslipidemias are disorders of lipoprotein metabolism that occur during childhood and adolescence, often persist into adulthood, and increase the risk of developing atherosclerotic lesions. This study aimed to assess the potential association between nutrient intake and dyslipidemia in Jordanian pediatric patients diagnosed with type 1 diabetes mellitus.
This cross-sectional study was conducted in Amman, Jordan, and involved 90 children and adolescents diagnosed with type 1 diabetes mellitus. Caregivers provided the following data: sex, age, type and dose of insulin, age at onset of type 1 diabetes, and level of physical activity. Anthropometric measurements were obtained using calibrated scales, and CDC growth charts were used to assess participants' body weight status. Nutrient intake was estimated using a 120-item food frequency questionnaire (FFQ) previously validated in Jordanian children and adolescents. Serum lipid levels, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured. Binary logistic regression was used to assess the relationship between nutrient intake and dyslipidemia.
The results indicated that 36.7% of study participants had dyslipidemia. There were no significant differences in nutrient intake between dyslipidemic and normolipidemic individuals, except for a significantly higher median intake of vitamin B12 in the dyslipidemic group compared to the normolipidemic group (3.6 versus 2.7 µg, P-value = 0.046).
This study found no significant association between the prevalence of dyslipidemia and nutrient intake in children and adolescents diagnosed with type 1 diabetes mellitus.
血脂异常是脂蛋白代谢紊乱,发生于儿童期和青少年期,常持续至成年期,并增加发生动脉粥样硬化病变的风险。本研究旨在评估约旦1型糖尿病患儿营养摄入与血脂异常之间的潜在关联。
本横断面研究在约旦安曼进行,纳入90例诊断为1型糖尿病的儿童和青少年。照料者提供以下数据:性别、年龄、胰岛素类型和剂量、1型糖尿病发病年龄以及身体活动水平。使用校准过的秤进行人体测量,并使用美国疾病控制与预防中心(CDC)生长图表评估参与者的体重状况。使用一份先前在约旦儿童和青少年中验证过的包含120个条目的食物频率问卷(FFQ)估算营养摄入量。测量血清脂质水平,包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。采用二元逻辑回归评估营养摄入与血脂异常之间的关系。
结果表明,36.7%的研究参与者患有血脂异常。血脂异常者与血脂正常者在营养摄入方面无显著差异,但血脂异常组维生素B12的中位数摄入量显著高于血脂正常组(3.6 μg对2.7 μg,P值 = 0.046)。
本研究发现,在诊断为1型糖尿病的儿童和青少年中,血脂异常患病率与营养摄入之间无显著关联。