Leiden University.
Leiden Institute for Brain and Cognition.
Child Dev. 2018 May;89(3):797-810. doi: 10.1111/cdev.13056. Epub 2018 Mar 13.
It was examined how ventral striatum responses to rewards develop across adolescence and early adulthood and how individual differences in state- and trait-level reward sensitivity are related to these changes. Participants (aged 8-29 years) were tested across three waves separated by 2 years (693 functional MRI scans) in an accelerated longitudinal design. The results confirmed an adolescent peak in reward-related ventral striatum, specifically nucleus accumbens, activity. In early to mid-adolescence, increases in reward activation were related to trait-level reward drive. In mid-adolescence to early adulthood decreases in reward activation were related to decreases in state-level hedonic reward pleasure. This study demonstrates that state- and trait-level reward sensitivity account for reward-related ventral striatum activity in different phases of adolescence and early adulthood.
研究考察了奖励相关的腹侧纹状体反应在青少年和成年早期是如何发展的，以及状态和特质水平的奖励敏感性个体差异与这些变化有何关系。参与者（年龄在 8 至 29 岁之间）在加速纵向设计中通过三次相隔 2 年的测试（693 次功能磁共振扫描）。结果证实了与奖励相关的腹侧纹状体（特别是伏隔核）活动的青少年高峰。在青少年早期到中期，奖励激活的增加与特质水平的奖励驱动有关。在青少年中期到成年早期，奖励激活的减少与状态水平的享乐奖励愉悦的减少有关。这项研究表明，状态和特质水平的奖励敏感性解释了不同阶段的青少年和成年早期与奖励相关的腹侧纹状体的活动。
