Yasar M, Erdi I, Kaya B
Bratisl Lek Listy. 2018;119(3):167-174. doi: 10.4149/BLL_2017_105.
We investigated the effects of atorvastatin and N-acetyl cysteine in decreasing ischemia-reperfusion damage after detorsion of a volvulus of the cecum and ascending colon.
Wistar albino rats (250-300 g) were divided into four groups. A cecal-ascending colon volvulus was created by the intestinal clockwise 720° rotation. At the end of one hour, the bowel was detorsioned. Group I (n = 7) was the sham (laparotomy) group, Group II (n = 7) the control (no treatment, volvulus or detorsion), Group III (n = 7) (N-acetyl cysteine administered ) , and Group IV (n = 7) (atorvastatin administered ) group. Blood samples were collected from each group via peripheral veins and centrifuged one hour after detorsion. The parameters of ischemia including malondialdehyde, glutathione peroxidase, catalase, and superoxide dismutase were then observed in the serous fluid.
Malondialdehyde and superoxide dismutase increased in the control group, whereas they were reduced in the Group III and Group IV (p = 0.005; p = 0.008, respectively). The glutathione peroxidase levels revealed no significant differences (p > 0.05), whereas the catalase levels of the group III was higher than in each of the other three groups (p < 0.001). Histopathological evaluation detected reduced lesioning of the organ in the groups which were given atorvastatin and N-acetyl cysteine.
Atorvastatin and of N-acetyl cysteine have a similar preventive effect in experimental ischemia-reperfusion injury (Tab. 8, Fig. 6, Ref. 24).
我们研究了阿托伐他汀和N-乙酰半胱氨酸对降低盲肠和升结肠扭转复位后缺血再灌注损伤的作用。
将体重250 - 300克的Wistar白化大鼠分为四组。通过肠道顺时针720°旋转造成盲肠-升结肠扭转。一小时后将肠扭转复位。第一组（n = 7）为假手术（剖腹术）组，第二组（n = 7）为对照组（未治疗，扭转或复位），第三组（n = 7）（给予N-乙酰半胱氨酸），第四组（n = 7）（给予阿托伐他汀）组。扭转复位后一小时通过外周静脉从每组采集血样并离心。然后在血清中观察缺血参数，包括丙二醛、谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶。
对照组丙二醛和超氧化物歧化酶升高，而第三组和第四组降低（分别为p = 0.005；p = 0.008）。谷胱甘肽过氧化物酶水平无显著差异（p > 0.05），而第三组过氧化氢酶水平高于其他三组中的每一组（p < 0.001）。组织病理学评估发现给予阿托伐他汀和N-乙酰半胱氨酸的组中器官损伤减轻。
阿托伐他汀和N-乙酰半胱氨酸在实验性缺血再灌注损伤中具有相似的预防作用（表8，图6，参考文献24）。
