Toth M I, Arya B, Pusztai R, Shiroki K, Beladi I
J Virol. 1987 Jul;61(7):2326-30. doi: 10.1128/JVI.61.7.2326-2330.1987.
Adenoviruses are generally weak interferon inducers, triggering chicken embryo fibroblast cells by a UV-resistant viral component, probably the capsid or capsid elements, to produce 50 to 100 IU of interferon per ml. Adenovirus types 12, 18, and 31, however, can induce by a UV-sensitive mechanism 10 to 20 times more interferon than other types do. By using mutant and recombinant adenoviruses, we demonstrated that early region 1A was responsible for the enhanced interferon production of chicken cells infected with adenovirus type 12.
腺病毒通常是较弱的干扰素诱导剂，通过一种对紫外线有抗性的病毒成分（可能是衣壳或衣壳成分）触发鸡胚成纤维细胞，使其每毫升产生50至100国际单位的干扰素。然而，12型、18型和31型腺病毒可通过一种对紫外线敏感的机制诱导产生比其他类型多10至20倍的干扰素。通过使用突变型和重组腺病毒，我们证明了早期区域1A负责增强感染12型腺病毒的鸡细胞的干扰素产生。
