Gottlow Jan
J Periodontol. 1993 Nov;64 Suppl 11S:1157-1165. doi: 10.1902/jop.1993.64.11s.1157.
Studies on periodontal wound healing have resulted in the development of the treatment modality known as "guided tissue regeneration" (GTR) based on a principle of guiding the proliferation of the various periodontal tissue components during healing following periodontal surgery. The first report of a human tooth treated according to the principle of GTR was presented 10 years ago by Nyman et al. Since then numerous clinical studies and animal experiments have been performed bringing the concept of GTR to a clinical reality. We also know that the results obtained through GTR therapy can be maintained on a long-term basis. The first generation of GTR devices has been non-resorbable, which calls for a second surgical procedure. This is avoided when bioresorbable devices become available. This paper suggests some demands regarding safety and efficacy criteria for both non-resorbable and bioresorbable devices. Results from recent animal experiments and clinical studies following the use of a bioresorbable device in GTR therapy are presented. J Periodontol 1993; 64:1157-1165.
关于牙周伤口愈合的研究促使了一种名为“引导组织再生”（GTR）的治疗方式的发展，该方式基于在牙周手术后愈合过程中引导各种牙周组织成分增殖的原则。10年前，尼曼等人首次报道了根据GTR原则治疗的一颗人类牙齿。从那时起，进行了大量的临床研究和动物实验，使GTR的概念成为临床现实。我们也知道，通过GTR治疗获得的结果可以长期维持。第一代GTR装置是不可吸收的，这需要进行第二次外科手术。当可生物吸收装置可用时，就可以避免这种情况。本文提出了一些关于不可吸收和可生物吸收装置的安全性和有效性标准的要求。文中介绍了在GTR治疗中使用可生物吸收装置后的近期动物实验和临床研究结果。《牙周病学杂志》1993年；64:1157 - 1165。
