University Hospital Frankfurt, Instiute of Clinical Pharmacology, Frankfurt/Main, Germany.
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
Mediators Inflamm. 2018 Feb 6;2018:5378284. doi: 10.1155/2018/5378284. eCollection 2018.
This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.
这篇综述概述了神经鞘脂超家族的组成部分及其定位和代谢。还介绍了神经鞘脂在细胞病理生理学中的生物学活性。最近的研究强调了神经鞘脂在炎症过程中的作用。我们总结了支持神经鞘脂成员在炎症的特定阶段发挥不同作用的新兴数据：（1）免疫细胞的迁移，（2）对外源物的识别，以及（3）免疫细胞的激活/分化。
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