一例急性淋巴细胞白血病的异常细胞遗传学
Unusual cytogenetics in a case of acute lymphoblastic leukemia.
作者信息
Morse H G, Hays T, Odom L F
出版信息
Med Pediatr Oncol. 1979;7(3):257-62. doi: 10.1002/mpo.2950070311.
PMID:295416
Abstract
The cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)-stimulated blood mitoses showed an abnormal karyotype with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA-stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from treatment.
摘要
本文呈现了一名急性淋巴细胞白血病患者的细胞遗传学研究情况。最初，大量未受刺激的和经植物血凝素（PHA）刺激的血液有丝分裂细胞显示出异常核型，伴有7号与12号染色体易位以及19号染色体三体。复发时，PHA刺激培养显示出克隆异常以及正常细胞中的双着丝粒染色体，后者可能是治疗所致。
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