Wozniak Karen L
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA.
J Fungi (Basel). 2018 Mar 15;4(1):36. doi: 10.3390/jof4010036.
The fungal pathogens and can cause life-threatening infections in immune compromised and immune competent hosts. These pathogens enter the host via inhalation, and respiratory tract innate immune cells such as dendritic cells (DCs) are one of the first host cells they encounter. The interactions between and innate immune cells play a critical role in the progression of disease in the host. This review will focus specifically on the interactions between and dendritic cells (DCs), including recognition/processing by DCs, effects of immune mediators on DC recruitment and activity, and the potential for DC vaccination against cryptococcosis.
真菌病原体可在免疫功能低下和免疫功能正常的宿主中引起危及生命的感染。这些病原体通过吸入进入宿主，呼吸道固有免疫细胞如树突状细胞（DCs）是它们遇到的首批宿主细胞之一。真菌病原体与固有免疫细胞之间的相互作用在宿主疾病进展中起关键作用。本综述将特别关注真菌病原体与树突状细胞（DCs）之间的相互作用，包括DCs的识别/处理、免疫介质对DC募集和活性的影响，以及DC疫苗预防隐球菌病的潜力。
