烟酸和烟酰胺对体内致癌作用的影响。

The influence of niacin and nicotinamide on in vivo carcinogenesis.

作者信息

Bryan G T

出版信息

Adv Exp Med Biol. 1986;206:331-8. doi: 10.1007/978-1-4613-1835-4_24.

Abstract

Data concerning effects of the essential vitamin niacin and its active form nicotinamide were evaluated. Dietary deficiencies and excesses of these nutrients by themselves do not appear to exert any influence on in vivo carcinogenesis in animals. Varying results were produced when nicotinamide was administered at pharmacologic doses concurrently with or following carcinogen administration to mice or rats. Some investigators found significantly increased tumor formation, whereas others reported a decreased effect or no effect. Epidemiologic studies have not investigated the relationship between niacin deficiency or excess and carcinogenesis in humans.

摘要

对必需维生素烟酸及其活性形式烟酰胺的作用数据进行了评估。这些营养素本身的饮食缺乏和过量似乎不会对动物体内致癌作用产生任何影响。当烟酰胺以药理剂量在给小鼠或大鼠施用致癌物的同时或之后施用时，会产生不同的结果。一些研究人员发现肿瘤形成显著增加，而另一些人则报告其作用减弱或无作用。流行病学研究尚未调查烟酸缺乏或过量与人类致癌作用之间的关系。