Institute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054, Chengdu, China.
Department of Physics, Government College University, 38000, Faisalabad, Pakistan.
Sci Rep. 2018 Mar 15;8(1):4576. doi: 10.1038/s41598-018-23105-y.
MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique. Toxicity-dependent parameters were assessed in a HeLa cell model after annealing the grown samples at 350 °C, 450 °C, and 550 °C. After the overall characterization, an analysis of toxicity caused by changes in the MgO nanostructure morphology was tested in a HeLa cell model using a neutral red assay and microscopy. The feasibility of using MgO for PDT was assessed. Empirical modelling was applied to corroborate the experimental results obtained from assessing cell viability losses and reactive oxygen species. The results indicate that MgO is an excellent candidate material for medical applications and could be utilized for its potential ability to upgrade conventionally used techniques.
氧化镁作为光动力疗法中致癌细胞破坏的一种有吸引力的选择，已被多项分析所证实。本研究的主要焦点是研究通过在不同退火温度下退火获得的形态不同的氧化镁纳米结构引起的毒性。智能（响应性）氧化镁纳米材料是一类非常有前途的纳米材料，其性质可以通过改变其尺寸、形态或其他相关特性来控制。这里研究的样品是通过共沉淀技术生长的。在将生长的样品在 350°C、450°C 和 550°C 下退火后，在 HeLa 细胞模型中评估了与毒性相关的参数。在 HeLa 细胞模型中使用中性红测定法和显微镜对氧化镁纳米结构形态变化引起的毒性进行了分析。评估了使用氧化镁进行 PDT 的可行性。应用经验模型来证实从评估细胞活力损失和活性氧获得的实验结果。结果表明，氧化镁是一种用于医疗应用的优秀候选材料，并且可以利用其潜在能力来升级传统使用的技术。
