Elshazali Hafiz Osama Hafiz, Elshazali Osama Hafiz, Elshazali Hafiz
Sixth Year Medical student, Faculty of Medicine, University of Khartoum, Sudan.
Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Sudan.
Sudan J Paediatr. 2017;17(2):49-55. doi: 10.24911/SJP.2017.2.6.
Low birth weight is a known comorbidity of congenital heart disease (CHD). This study examines the relationship between CHD and birth weight of singletons, while attempting to remove factors that influence birth weight, and assesses the impact of CHD on growth in later life. The main objective is to study the relationship between birthweight and CHD. This is a cross-sectional study of 141 samples, covering all patients who were referred to the Paediatric Echocardiography Lab at Ahmed Gasim Cardiac Centre between September and October 2016. Infants with genetic syndromes or other major extracardiac abnormalities were excluded. The findings of this study clearly demonstrate that infants with CHD are more likely to be of low birth weight than the general Sudanese population, by a factor of 2.6. Of the sample, 31.9% were born with low or very low birthweight. The mean birth weight of the cases was 2.59 kg, which is 17.3% and 542.4 g less than the national average. CHD that cause a decrement in birth weight in a descending order of severity were atrial septal defect (-721 g/23%), patent ductus arteriosus (-669 g/21%), ventricular septal defect (-610 g/19%), pulmonary stenosis (-548 g/13%) and tetralogy of Fallot (248 g/8%). Pre/postnatal growth impairment is a common feature among children with CHD. No statistically significant relationship was found between the degree of birth weight/weight to age decrement and the specific type of hemodynamic disturbance. Our results are comparable to other studies that have been undertaken. However, Sudanese patients display larger birthweight deficits than other populations.
低出生体重是先天性心脏病（CHD）已知的合并症。本研究探讨了单胎CHD与出生体重之间的关系，同时试图排除影响出生体重的因素，并评估CHD对后期生长的影响。主要目的是研究出生体重与CHD之间的关系。这是一项对141个样本的横断面研究，涵盖了2016年9月至10月间转诊至艾哈迈德·加西姆心脏中心儿科超声心动图实验室的所有患者。患有遗传综合征或其他主要心外异常的婴儿被排除在外。本研究结果清楚地表明，患有CHD的婴儿出生时体重低的可能性是苏丹普通人群的2.6倍。在样本中，31.9%的婴儿出生时体重低或极低。病例的平均出生体重为2.59千克，比全国平均水平低17.3%，即低542.4克。按严重程度降序排列，导致出生体重下降的CHD依次为房间隔缺损（-721克/23%）、动脉导管未闭（-669克/21%）、室间隔缺损（-610克/19%）、肺动脉狭窄（-548克/13%）和法洛四联症（248克/8%）。出生前/后的生长发育受损是CHD患儿的常见特征。出生体重/体重相对于年龄的下降程度与特定类型的血流动力学紊乱之间未发现统计学上的显著关系。我们的结果与其他已开展的研究相当。然而，苏丹患者的出生体重缺陷比其他人群更大。
