抗丙型肝炎病毒阴性血液透析患者中的丙型肝炎病毒血症：我们是否需要丙型肝炎病毒核糖核酸检测试验？

HCV viraemia in anti-HCV-negative haemodialysis patients: Do we need HCV RNA detection test?

作者信息

Papadopoulos Nikolaos, Griveas Ioannis, Sveroni Eirini, Argiana Vasiliki, Kalliaropoulos Antonios, Martinez-Gonzalez Beatriz, Deutsch Melanie

机构信息

1 1st Department of Internal Medicine, 417 Army Share Fund Hospital of Athens, Athens, Greece.

2 Nephrology Department, 417 Army Share Fund Hospital of Athens, Athens, Greece.

出版信息

Int J Artif Organs. 2018 Mar;41(3):168-170. doi: 10.1177/0391398817752326. Epub 2018 Feb 13.

DOI:10.1177/0391398817752326

PMID:29546809

Abstract

BACKGROUND

Hepatitis C virus (HCV) infection is still common among dialysis patients, but the natural history of HCV in this group is not completely understood. The KDIGO HCV guidelines of 2009 recommend that chronic haemodialysis patients be screened for HCV antibody upon admission to the dialysis clinic and every 6 months thereafter if susceptible to HCV infection. However, previous studies have shown the presence of HCV viraemia in anti-HCV-negative haemodialysis patients as up to 22%.

OBJECTIVES

To evaluate the presence of HCV viraemia, using HCV RNA detection, among anti-HCV-negative haemodialysis patients from a tertiary dialysis unit in Athens.

METHODS

We enrolled 41 anti-HCV-negative haemodialysis patients diagnosed with third-generation enzyme immunoassay. HCV viraemia was evaluated using a sensitive (cut-off: 12 IU/mL) reverse transcriptase polymerase chain reaction (COBAS AmpliPrep/TaqMan system) for HCV RNA.

RESULTS

None of the 41 anti-HCV-negative haemodialysis patients were shown to be viraemic.

CONCLUSIONS

Routine HCV RNA testing appears not to be necessary in anti-HCV-negative haemodialysis patients.

摘要

背景

丙型肝炎病毒（HCV）感染在透析患者中仍然很常见，但该群体中HCV的自然史尚未完全明了。2009年KDIGO HCV指南建议，慢性血液透析患者在进入透析诊所时应进行HCV抗体筛查，若易感染HCV，则此后每6个月筛查一次。然而，先前的研究表明，抗HCV阴性的血液透析患者中HCV病毒血症的发生率高达22%。